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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

The Effects of Trigonella Foenum-graecum L. on Post-surgical Adhesion Band Formation

Author(s): Seyedeh Elnaz Nazari, Nima Khalili-Tanha, Shima Mehrabadi, Leila Mobasheri, Hamideh Naimi, Fatemeh khojasteh-Leylakoohi, Mohammad Dashtiahangar, Hamid Fiuji, Hassan Mottaghi Moghaddam Shahri, Sayyed Hadi Sayyed Hoseinian, Seyed Mahdi Hassanian, Hamid Reza Ghorbani, Mohsen Aliakbarian, Gordon A Ferns, Majid Khazaei* and Amir Avan*

Volume 21, Issue 8, 2024

Published on: 05 May, 2023

Page: [1400 - 1405] Pages: 6

DOI: 10.2174/1570180820666230417100810

Price: $65

Abstract

Background: Intra-abdominal adhesions are severe complications which occur after abdominal surgery. Currently, no specific anti-adhesive medications can completely prevent Intra-abdominal adhesion formation. Therefore, recent studies are exploring new approaches for preventing this complication. Anti-inflammatory properties of Trigonella Foenum-graecum L. (Fenugreek) have been reported in various studies. In this experiment, a murine model was used to evaluate the potential anti-adhesive activity of Fenugreek in vivo.

Objective: This experiment aimed to examine the anti-adhesive activity of Fenugreek in the prevention of postsurgical Intra-abdominal adhesions.

Methods: We have adhered to the ARRIVE guidelines during these experimental studies. After abdominal surgery, for nine days, Fenugreek (400 mg/kg) was given by gavage to male Wistar rats (n = 6). Following that, all animals were sacrificed to assess the anti-inflammatory and anti-fibrotic effects of Fenugreek using Hematoxylin & eosin staining and Masson’s trichrome staining.

Results: Our results showed that Fenugreek hydro-alcoholic extract could significantly reduce the adhesion band formation based on Nair and Leach Scoring system (P < 0.01). The histological assessment also represented less inflammatory cell infiltration and less collagen deposition in the treatment group than in the positive control group (P < 0.01).

Conclusion: This study showed that Fenugreek extract could attenuate post-surgical adhesion band formation by inhibiting pathological responses (Inflammation and fibrosis) following surgery.

Keywords: Trigonella Foenum-graecum L., fenugreek, intra-abdominal adhesion, inflammation, fibrosis, inflammatory cell infiltration.

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