Title:Research Progress of Chitosan-based Multifunctional Nanoparticles
in Cancer Targeted Therapy
Volume: 31
Issue: 21
关键词:
壳聚糖，纳米颗粒，靶向递送，癌症治疗，纳米药物递送系统(dds)，生物相容性。
摘要: Conventional tumor therapeutic modalities, such as radiotherapy, chemotherapy,
and surgery, involve low tumor inhibition efficiency, non-targeted drug delivery, and
side effects. The development of novel and practical nano-drug delivery systems (DDSs)
for targeted tumor therapy has become particularly important. Among various bioactive
nanoparticles, chitosan is considered a suitable candidate for drug delivery due to its nontoxicity,
good biocompatibility, and biodegradability. The amino and hydroxyl groups of
chitosan endow it with the diverse function of chemical modification, thereby improving
its physical and biological properties to meet the requirements of advanced biomedical
applications. Therefore, it is necessary to review the property and applications of chitosan-
based materials in biomedicine. In this review, the characteristics of chitosan related
to its applications are first introduced, and then the preparation and modification of
chitosan-based nanoparticles, including the function tailoring of chitosan-modified nanoparticles,
are demonstrated and discussed. Finally, the opportunities and challenges of chitosan-
based nanomaterials in this emerging field are proposed from the perspective of the
rational and systematic design for the biomedicine field.
