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Current Medicinal Chemistry

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General Review Article

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Author(s): Sahar Golpour Hamedani, Makan Pourmasoumi, Gholamreza Askari*, Mohammad Bagherniya, Thozhukat Sathyapalan and Amirhossein Sahebkar*

Volume 31, Issue 20, 2024

Published on: 22 June, 2023

Page: [2944 - 2954] Pages: 11

DOI: 10.2174/0929867330666230413093409

Price: $65

Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.

Keywords: Pharmaceutical, herbal, chemical compounds, nutrition, neuroglobin (Ngb), iron chelators.

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