Title:Assessment of Wound Healing Potential of Simvastatin Emulgel in Rat
Excision Wound Model
Volume: 21
Issue: 9
Author(s): Surbhi Gupta, Anubhav Anand*Ramesh Kumar Gupta
Affiliation:
- Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Gazipur,
Balram Road, Lucknow, 226020, Uttar Pradesh, India
Keywords:
Simvastatin, emulgel, sesame oil, carbopol 934, tween 80, wound healing, hydroxyproline.
Abstract:
Background: Microorganisms can infect wounds and disrupt healing by causing inflammation
and tissue injury.
Objective: Simvastatin (SIM) is reported to have antibacterial activity; therefore, this research is designed
to evaluate the efficacy of simvastatin emulgel in wound healing.
Methods: The simvastatin emulgel was assessed for physical appearance, rheological behaviour, spreadability,
pH, ex vivo drug release and in vivo activity. The wound-healing activity was assessed by percent
wound contraction, hydroxyproline estimation and histopathological evidence in wound-induced albino
rats.
Results: The simvastatin emulgel exhibited viscosity and spreadability of 6875 ± 531.21 mPa.s and 10.15
± 0.31 g.cm/sec, respectively. The simvastatin emulgel exhibited wound contraction in wound healing
studies compared to the reference product (p < 0.05). This activity was statistically significant (p < 0.05)
in comparison to the control. The hydroxyproline content supported the wound-healing promoting effect
of simvastatin emulgel, and marked improvements in the skin histological architecture were seen in the
histopathological study.
Conclusion: The study manifested the promising potential of simvastatin emulgel in speeding the healing
of rat wounds with epithelization. Therefore, the designed simvastatin emulgel can be used as an option
for the conventional topical dosage form.
