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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

Covid-19 Prevention and Treatment by Targeting Fc-fusion Proteins: An Experience to Fight Emerging Diseases

Author(s): Hamed Zare, Tahereh Farkhondeh, Hamid Bakherad, Hengame Sharifi, Maryam Hosseinzade Shirzeyli, Saeed Samarghandian and Fahimeh Ghasemi*

Volume 24, Issue 4, 2024

Published on: 18 May, 2023

Page: [428 - 434] Pages: 7

DOI: 10.2174/1566524023666230410093243

Price: $65

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Abstract

The coronavirus disease 2019 (Covid-19) pandemic has been considered a major threat to human health. Effective therapeutic approaches are urgently required. Spike protein and the Angiotensin-converting enzyme 2 (ACE2) receptors have critical roles in SARS-CoV-2 infection. As a result, these two proteins are considered potential targets for the development of a wide variety of biotherapeutics and vaccines for controlling Covid-19. The fusion proteins have desirable medicinal properties, including high serum half-life, stability, and solubility in the body. Moreover, other Fc-fusion proteins used to treat other diseases have no known side effects. These Fc-fusion proteins are valuable biopharmaceuticals and have been proposed as therapeutic candidates for the treatment and prevention of Covid-19 owing to their potential therapeutic benefits.

Keywords: Fc-fusion proteins, Covid-19, SARS-CoV-2, Spike protein, ACE2, receptor.

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