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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Metal Free Simple and Efficient Synthesis of Tetrahydropyrrolo[1,2-a]- Pyrazine Based on a Cascade Strategy

Author(s): Chakrapani Sanaboina, Samir Kumar Mandal* and Samaresh Jana*

Volume 20, Issue 10, 2023

Published on: 18 May, 2023

Page: [916 - 921] Pages: 6

DOI: 10.2174/1570178620666230327114033

Price: $65

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Abstract

A simple and efficient synthesis of pyrrolo[1,2-a]pyrazine using Schiff base formation, intramolecular cyclization (or N-alkylation), and Pictet–Spengler type reaction (hetero-aromatisation) has been developed. In this chemistry, metal-free, cost and time-effective processes have been highlighted to afford the complex nitrogenous scaffold using simple starting materials.

Keywords: Pyrrolyl-ethanamine, halo-aldehyde, Pyrrolo[1, 2-a]pyrazines, cascade reaction, Pictet-Spengler reaction, heteroaromatization.

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