Title:Therapeutic and Diagnostic Agents based on Bioactive Endogenous
and Exogenous Coordination Compounds
Volume: 31
Issue: 3
关键词:
金属基配位复合物,治疗和诊断剂,生物学和药用意义,外源性,生物活性,金属基化合物。
摘要: Metal-based coordination compounds have very special place in bioinorganic
chemistry because of their different structural arrangements and significant application in
medicine. Rapid progress in this field increasingly enables the targeted design and
synthesis of metal-based pharmaceutical agents that fulfill valuable roles as diagnostic or
therapeutic agents. Various coordination compounds have important biological functions,
both those initially present in the body (endogenous) and those entering the organisms
from the external environment (exogenous): vitamins, drugs, toxic substances, etc. In the
therapeutic and diagnostic practice, both the essential for all living organisms and the
trace metals are used in metal-containing coordination compounds. In the current review,
the most important functional biologically active compounds were classified group by
group according to the position of the elements in the periodic table.