Title:Pharmacological Progress of Mitophagy Regulation
Volume: 21
Issue: 5
Author(s): Sheikh Arslan Sehgal*, Hao Wu, Muhammad Sajid, Summar Sohail, Muhammad Ahsan, Gulnaz Parveen, Mehreen Riaz, Muhammad Saleem Khan, Muhammad Nasir Iqbal and Abbeha Malik
Affiliation:
- Department of Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan
- Department of
Bioinformatics, University of Okara, Okara, Pakistan
Keywords:
Mitophagy, pharmacology, mitochondria, neurological disorders, power management system, mitochondrial quality control.
Abstract: With the advancement in novel drug discovery, biologically active compounds are considered
pharmacological tools to understand complex biological mechanisms and the identification of potent
therapeutic agents. Mitochondria boast a central role in different integral biological processes and mitochondrial
dysfunction is associated with multiple pathologies. It is, therefore, prudent to target mitochondrial
quality control mechanisms by using pharmacological approaches. However, there is a scarcity of
biologically active molecules, which can interact with mitochondria directly. Currently, the chemical
compounds used to induce mitophagy include oligomycin and antimycin A for impaired respiration and
acute dissipation of mitochondrial membrane potential by using CCCP/FCCP, the mitochondrial uncouplers.
These chemical probes alter the homeostasis of the mitochondria and limit our understanding of the
energy regulatory mechanisms. Efforts are underway to find molecules that can bring about selective removal
of defective mitochondria without compromising normal mitochondrial respiration. In this report,
we have tried to summarize and status of the recently reported modulators of mitophagy.
