Current Neuropharmacology

Journal: Current Neuropharmacology
Guest editor(s): Smathorn Thakolwiboon
Co-Guest Editor(s): Pei Shang and Nisa Vorasoot

Introduction

We are excited to invite submission for a special issue dedicated to exploring the intricacies of multiple sclerosis (MS), an inflammatory disease of central nervous system (CNS) causing demyelination and neuronal injury. This issue aims to highlight the recent advancement in the understanding of disease mechanism and therapeutic developments in multiple sclerosis and related disorder. While several FDA-approved disease-modifying therapies effectively reduced relapses and radiologic activity. The understanding in the mechanism and therapeutic application of continuous neurodegeneration remains an unmet need. This special issue seeks to delve into the emerging concepts in the pathophysiology and therapeutic advancements of multiple sclerosis and related disorders such as aging and immunosenescence, the interplay of genetic and environmental factors, compartmentalized inflammation and blood brain barrier, neurodegeneration and re-myelination, etc. Here, we raised this Research Topic, focusing on the molecular mechanisms and state-of-art therapeutic targets of MS and the relationship between MS and neuromyelitis optica spectrum disorders, myelin oligodendrocyte glycoprotein antibody-associated disease or other autoimmune conditions. In this Research Topic, we welcome all types of articles including Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Tria, and Opinion articles that cover.

Keywords

Autoimmune, demyelination, multiple sclerosis, neuroinflammation, neuropharmacology, oligodendrocyte

Sub-topics

1) Multiple sclerosis across lifespan

2) Immunosenescence and multiple sclerosis and related disorders

3) Genetic and environmental factors in multiple sclerosis and related disorders

4) Emerging concept in pathophysiology and therapeutic targets in multiple sclerosis and related disorders

3) Blood brain barrier and multiple sclerosis and related disorders: mechanism of disease and therapeutic application

3) Neuroregeneration and re-myelination in multiple sclerosis and related disorders

Journal: Current Neuropharmacology
Guest editor(s): Zhong Chen

Introduction

Cerebral ischemia, a condition in which there is inadequate blood supply to the brain, ranks as one of the leading causes of disability and mortality globally. Despite its prevalence and severity, efficacious treatment options for this debilitating disorder remain limited. Recent scientific explorations have delved deeply into the pathological mechanisms underlying cerebral ischemia, uncovering the pivotal role of intercellular communication in both ischemic injury and the subsequent regeneration. Intercellular communications during cerebral ischemia occur in various ways, including: (1) direct physical contacts, e.g. those mediated by adhesion molecules, facilitating immediate responses and cellular coordination. (2) Chemical signaling pathways, which involve the release and reception of cytokines, growth factors, and neurotransmitters, orchestrating inflammation, repair, and survival signals. (3) Extracellular vesicle-mediated communication, where microvesicles and exosomes act as sophisticated couriers, ferrying genetic material, proteins, and lipids between cells to modulate immune responses and promote cellular survival or regeneration. (4) Transcellular exchanges through physical channels, such as gap junctions and nanotubes, enabling the rapid dissemination of ions, metabolites, and signaling molecules after stress. Investgatons into these communication pathways may advance our understanding of pathological mechanisms underlying ischemic stroke and pave the way for developing therapeutic strategies that target specific aspects of the ischemic responses.

Keywords

Cerebral ischemia, intercellular communications, neuroprotection, neurovascular unit, exosomes, inflammation, glial cells, neurogenesis.

Sub-topics

The sub-topics to be covered within the issue should be provided:

1. Glia-Neuron Interactions in cerebral ischemia
2. Molecular Insights into Adhesion-Mediated Cell Coordination Post-Ischemic Stroke
3. Chemokines and Cytokines in Neuroinflammation Post-Ischemic Stroke
4. Decoding the Roles of Extracellular Vesicles in Neuroprotection and Regeneration
5. Gap Junctions and Nanotubes: Highways of Metabolic and Signaling Exchange in Ischemic Stress
6. Cutting-Edge Technologies in deciphering Intracellular Communications Post-Ischemic Stroke
7. Targeting Intracellular Communication Pathways for Innovative Therapies in Cerebral Ischemia

Journal: Current Neuropharmacology
Guest editor(s): István BÓKKON
Co-Guest Editor(s): Császár-Nagy NOÉMI

Introduction

The researches of the last two decades indicate that the role of the intestinal system can be fundamental in most diseases. The bidirectional Microbiota - Gut –Brain - Axis (MGBA) includes the central nervous system (CNS), the autonomic nervous system (ANS), the vagus nerve, the neuroendocrine system, neuroimmune systems, the HPA axis, and the gut microbiota and its metabolites. This allows the CNS and the gut system to communicate with each other continuously. The MGBA could contribute to the development of numerous intestinal and extraintestinal diseases, among which are IBS, FM, chronic pain, stroke, lung disease, obesity, type 2 diabetes, insulin resistance, psoriasis, cancer, celiac disease, metabolic syndrome, and nervous system disorders. In this special issue, we invite manuscript submissions (Reviews, Full-length articles, Research articles Mini Reviews) addressing the pivotal roles of Microbiota - Gut - Brain - Axis in mood and neuropsychiatric disorders. We welcome new ideas and molecular models/mechanisms that are well written and scientifically could be supported. Please, in your possible article, outline your scientific idea/model in a quality figure.

Keywords

Probiotics, Synbiotics, Prebiotics, Fecal microbiota transplantation, Combination of THC and cannabidiol (CBD),Post-biotics (e.g. SCFAs), Bioactive natural products, Cognitive behavioural therapy, Gut- directed hypnotherapy.

Sub-topics

1. Gut serotonin and Microbiota- Gut - Brain Axis
2. Gut dopamine and Microbiota- Gut - Brain Axis
3. SCFAs and Microbiota- Gut - Brain Axis
4. Platelets and Microbiota- Gut - Brain Axis
5. Stress and Microbiota- Gut - Brain Axis

Journal: Current Neuropharmacology
Guest editor(s): Vladimir Kosonogov

Introduction

Emotion regulation is a critical aspect of mental well-being and interpersonal relationships. To fully understand and effectively address emotion regulation, an integrative approach that considers pharmacological, neurobiological, and psychological frameworks is essential. Pharmacological interventions, such as medications targeting neurotransmitter imbalances, can play a significant role in managing emotional dysregulation. Understanding how these medications interact with the brain's neurobiological processes is crucial for optimizing treatment outcomes. Additionally, the psychological aspects of emotion regulation, including cognitive-behavioral strategies and mindfulness techniques, are equally important. By integrating these psychological interventions with pharmacological and neurobiological approaches, a more comprehensive and personalized treatment plan can be developed. Studying emotion regulation in an integrative way allows for a holistic understanding of the complexities involved in managing emotions. This approach can lead to more effective interventions and better outcomes for individuals struggling with emotional dysregulation.

Keywords

Emotion dysregulation, neurotransmitters, personalized treatment, neurophysiology, psychotherapeutic practices.

Sub-topics

1. Pharmacological aspects of emotion regulation
2. Neurotransmitters involved in emotion regulation
3. Pharmacological interventions in emotion dysregulation
4. Neurophysiology of emotion regulation
5. Peripheral and metabolic mechanisms of emotion regulation
6. Emotion dysregulation in clinical samples
7. Cutting-Edge Technologies in deciphering Intracellular Communications Post-Ischemic Stroke
8. Psychotherapeutic and educational practices to improve emotion regulation