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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Mini-Review Article

Role of Supplements in the Management of COVID-19 - A Comprehensive Review

Author(s): Rajkapoor Balasubramanian*, Naina Mohamed Pakkir Maideen, Sudha Muthusamy, Sambathkumar Ramanathan and Mohamed Harsath Jahir Hussain

Volume 23, Issue 5, 2023

Published on: 28 April, 2023

Article ID: e100323214544 Pages: 12

DOI: 10.2174/1871526523666230310094646

Price: $65

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Abstract

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS CoV- 2-targeting drugs and the therapeutic agents assisting in the management of COVID-19 complications. This review focuses on the supplements like vitamins, minerals, herbal constituents, and others that help prevent or manage negative outcomes among COVID-19 patients. The literature was searched in databases such as Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, EMBASE, the Directory of Open Access Journals (DOAJ), and reference lists to identify relevant articles. The vitamins, including vitamin C, and vitamin D, minerals such as zinc, selenium, and copper, herbal constituents like thymoquinone, curcumin, naringenin, quercetin, and glycyrrhizin, and other supplements, including N-acetylcysteine and melatonin. Melatonin have been identified as having the potential to manage patients with COVID-19 along with standard care. Some of the ongoing clinical trials are investigating the effectiveness of different supplements among COVID-19 patients.

Keywords: SARS-CoV-2, COVID-19, vitamin C, vitamin D, zinc, selenium, copper, thymoquinone, curcumin, naringenin, quercetin, glycyrrhizin, N-acetylcysteine, melatonin.

Graphical Abstract

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