Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Mini-Review Article

A Mini-Review on the Chemical Constituents and Biological Activities of Lysimachia capillipes Hemsl.

Author(s): Fujunrui Jiang, Jianping Yong*, Shaoji Lu, Ruiwen Huang, Danian Tian and Canzhong Lu*

Volume 10, Issue 1, 2024

Published on: 17 April, 2023

Article ID: e070323214431 Pages: 8

DOI: 10.2174/2215083809666230307104125

Price: $65

conference banner
Abstract

Lysimachia capillipes Hemsl. is an annual flowering plant, mainly distributed in some parts of Asia. In the early 1970s, it was discovered by the folk of Le'an county, Jiangxi province. Lysimachia capillipes Hemsl., contains many bioactive components (flavonoids, saponins, volatile oils, organic acids, etc.) and has a wide spectrum of pharmacological activities. This plant medicine was used in the treatment of cold cough, asthma, rheumatism, pain, irregular menstruation, neurasthenia, restoring deficiency, expelling roundworm, anti-tumor, etc. in Chinese folk. In this minireview, the progress on the chemical constituents and biological activities of Lysimachia capillipes Hemsl., was comprehensively summarized by searching the CNKI, PubMed, Web of Science, Scopus, and Google Scholar databases using “Lysimachia capillipes Hemsl.” or “Manshanxiang” as the keywords. This article may provide a reference for researchers for further study of Lysimachia capillipes Hemsl.

Keywords: Lysimachia capillipes Hemsl., chemical constituents, flavonoids, saponins, anticancer activity, antivirus activity, antibacterial activity.

Graphical Abstract
[1]
Xu YS, Ding YH, Gao J, Zhang S. Research progress on antitumor effects of Lysimachia capillipes Hemsl. Zhongguo Yaolixue Tongbao 2018; 34(11): 1489-92.
[2]
Chinese Medicinal Material Standards of Jiangxi Province. Shanghai Scientific & Technical Publishers 2014; pp. 337-9.
[3]
Zhang KY, Hong T, Qian Y, et al. Separation identification of chemical constituents of Lysimachia capillipes. Zhongguo Shiyan Fangjixue Zazhi 2019; 25(6): 156-62.
[4]
Editorial Committee of Chinese Flora, Chinese Academy of Sciences. Flora of Chin. Science Press: Beijing 1989; Vol. 59(1): pp. 38.
[5]
People’s Government of Jiangxi. Province Standard of Chinese medicinal materials of Jiangxi Province. Jiangxi Sci. Tech. Press 1997; pp. 210-2.
[6]
Jiang ZS, Hu Q, Zheng SS, Lan XY. Clinical and experimental study on the anti - influenza virus of Manshanxiang. Jiangxi Med J 1980; 5: 6-9.
[7]
Zheng YK, Jiang ZS, Zhou LL. The water solution of Manshanxiang to influenza virus inhibition effect observation. Acta Microbiol Sin 1973; 13(2): 162.
[8]
Yang YS, Liu LY, Zhang KY, et al. Simultaneous determination of two specific flavonoid glycosides in Manshanxiang tablets by HPLC. Yaowu Fenxi Zazhi 2020; 40(8): 1371-5.
[9]
Hong T, Qian Y, Yang YS. Review on chemical compositions and antitumor activities of Lysimachia capillipes Hemsl. Natur Prod Res & Dev 2018; 30(6): 1092-7.
[10]
Liu Y, Zhang Q, Chen M, Xu YL, Luo GM, Lin GB. Study on pharmacognosy of Manshanxiang. Lishizhen Med Mat Medi Res 2015; 26(9): 2178-80.
[11]
Xie C, Xu LZ, Zhao BH, Yang SL. Study on the chemical constituents of Lysimachia capillipes. Chin Tradit Herbal Drugs 2000; 31(2): 3-5.
[12]
Xie C, Xu LZ, Zhao BH, Yang SL. Studies on the chemical constituents of Lysimachia capillipes Hemsl. Chin Chem Lett 1998; 9(12): 1095-6.
[13]
Xie C, Xu LZ, Luo XZ, Zhong Z, Yang SL. Flavonol glycosides from Lysimachia capillipes. J Asian Nat Prod Res 2002; 4(1): 17-23.
[http://dx.doi.org/10.1080/10286020290019659] [PMID: 11991188]
[14]
Tian JK, Zou ZM, Xu LZ, Xie C, Yang SL. Studies on chemical constituents of Lysimachia capillipes. Chinese Pharml J 2006; 41(3): 171-3.
[15]
Tian JK, Zou ZM, Xu LZ, Yang SL. Advances in studies on chemical constituents of Lysimachia genus. Foreign Med Sci 2002; 24(2): 80-5.
[16]
Tian JK. Studies on the chemical constituents of two medicinal plants of Lysimachia genus. PhD Thesis, Peking Union Medical College and Chinese Academy of Medical Sciences: Beijing, May 2002.
[17]
Tian JK, Zou ZM, Xu LZ, et al. Two new triterpenoid saponins from Lysimachia capillipes Hemsl. Acta Pharm Sinica 2004; 39(9): 722-5.
[PMID: 15606022]
[18]
Tian JK, Xu LZ, Zou ZM, Yang SL. Two new triterpene saponins from Lysimachia capillipes. J Asian Nat Prod Res 2006; 8(5): 439-44.
[http://dx.doi.org/10.1080/10286020500173259] [PMID: 16864460]
[19]
Tian JK, Xie C, Zou ZM, Xu LZ, Yang SL. Two novel saponins from Lysimachia capillipes. Chin Chem Lett 2005; 16(12): 1607-10.
[20]
Ying HM, Chen RZ, Guo DW, Yu TL. Quantitative determination and the related anti-tumor research of saponins in Lysimachia capillipes. Proceedings of the 2010 Chinese Pharmaceutical Congress and the 10th Chinese Pharmacists Week Proceedings. Tianjin, China 2010; pp. November 5-8, 2010; 2672-9.
[21]
Ding ZH, Wu JY. The volatile oil of Lysimachia capillipes. Acta Botanica Yunnaica 1989; 11(2): 209-14.
[22]
Chen DD, Yang YS, Zhang KY, Wang D, Hong T. Chemical constituents from Lysimachia capillipes. Zhongchengyao 2021; 43(12): 3360-6.
[23]
Fei Z, Wu K, Chen Y, Wang B, Zhang S, Ma S. Capilliposide isolated from Lysimachia capillipes Hemsl. induces ROS generation, cell cycle arrest, and apoptosis in human nonsmall cell lung cancer cell lines. Evid Based Complement Alternat Med 2014; 2014: 1-11.
[http://dx.doi.org/10.1155/2014/497456] [PMID: 24523821]
[24]
Gong MH. Antitumor effect and mechanisms of capilliposide hydrolysate LC-A from Lysimachia capillipes Hemsl. Master Thesis, Shandong University of Traditional Chinese Medicine: Jinan, June 2016.
[25]
Zhang S, Xu Y, Jin E, et al. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance. Acta Pharmacol Sin 2017; 38(1): 100-9.
[http://dx.doi.org/10.1038/aps.2016.116] [PMID: 27840409]
[26]
Chen SM. LC capilliposide increases sensitivity to irradiation in non-small cell lung cancer cells. PhD Thesis, Zhejiang Chinese Medical University: Hangzhou, March 2016.
[27]
Wu K, Wang B, Xu Y, et al. Lysimachia capillipes capilliposide C restores radiation sensitivity in radiation resistant lung cancer cells by enhancing ERRFI1 expression. J Thorac Oncol 2019; 14(10): S959-60.
[http://dx.doi.org/10.1016/j.jtho.2019.08.2097]
[28]
Xu Y, Rong YM, Liu XB, Ying HM, Zou LB, Tian JK. Experimental studies on anti-tumor effects of Capilliposide. Zhongguo Yaolixue Tongbao 2012; 28(4): 545-9.
[29]
Li RY. Anti-tumor mechanisms of four monomer compounds on prostate and breast cancer cell lines. PhD Thesis, Zhejiang University: Hangzhou, July 2016.
[30]
Li R, Zhang L, Zhang L, et al. Capilliposide C derived from Lysimachia capillipes Hemsl. inhibits growth of human prostate cancer PC3 cells by targeting caspase and MAPK pathways. Int Urol Nephrol 2014; 46(7): 1335-44.
[http://dx.doi.org/10.1007/s11255-013-0641-6] [PMID: 24554216]
[31]
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3): 209-49.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]
[32]
Stathis A, Moore MJ. Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol 2010; 7(3): 163-72.
[http://dx.doi.org/10.1038/nrclinonc.2009.236] [PMID: 20101258]
[33]
Yu XG, He YH, Zhang XF. Effect of Lysimachia capillipes with gemcitabine on proliferation and apoptosis of pancreatic cancer BxPC-3 cells and related mechanism. Zhejiang Med J 2018; 40(2): 121-5.
[34]
Wang Y, Zhang XF, Wang J, et al. The anti-cholangiocarcinoma effect and its mechanism of Lysimachia capilliposide in combination with 5-fluorouracil. J Zhejiang Chinese Med Uni 2018; 42(12): 989-95.
[35]
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6): 394-424.
[36]
Pokhriyal R, Hariprasad R, Kumar L, Hariprasad G. Chemotherapy resistance in advanced ovarian cancer patients Biomark Cancer 2019; 11: 1179299X1986081.
[http://dx.doi.org/10.1177/1179299X19860815] [PMID: 31308780]
[37]
Zhang K, Ying H, Zhao R, Chen Y, Deng Q. Capilliposide from Lysimachia capillipes promotes terminal differentiations and reverses paclitaxel resistance in A2780T cells of human ovarian cancer by regulating Fos/Jun pathway. Chin Herb Med 2022; 14(1): 111-6.
[http://dx.doi.org/10.1016/j.chmed.2021.09.009] [PMID: 36120123]
[38]
Hua YH, Hu QY, Pu YF, Tang Q, Ma SL. The Antitumor effect of capilliposide on nasopharyngeal cancer cell line CNE-2 in vitro. China Cancer 2014; 23(7): 597-600.
[39]
Shen Z, Xu L, Li J, Zhang N. Capilliposide C sensitizes esophageal squamous carcinoma cells to oxaliplatin by inducing apoptosis through the PI3K/Akt/mTOR pathway. Med Sci Monit 2017; 23: 2096-103.
[http://dx.doi.org/10.12659/MSM.901183] [PMID: 28463955]
[40]
Jiang ZS, Hu Q, Wang Y, Peng M. Experimental study of Lysimachia capillipes induced interferon against influenza virus. Jiangxi Med J 1988; 5: 420-2.
[41]
Zheng LH, Wu QC, Chen QL, Lin JY, Liao YP. Decolorization optimization of saponins from Lysimachia capillipes Hemsl. by activated carbon and its antimicrobial activity. China Food Additives 2021; 32(11): 67-72.
[42]
Han H, Yang Y, Wu Z, et al. Capilliposide B blocks VEGF-induced angiogenesis in vitro in primary human retinal microvascular endothelial cells. Biomed Pharmacother 2021; 133: 110999.
[http://dx.doi.org/10.1016/j.biopha.2020.110999] [PMID: 33227710]
[43]
Aisa HJ, Yong JP, Lv QY, Wu T. (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8a-octahydroazulen-5-yl)acrylic acid (rupestonic acid). Acta Crystallogr 2008; E64: o479.
[44]
Yong JP, Lv QY, Aisa HA. Synthesis of (5R,8R)-2-(3,8- dimethyl-2-oxo-1,2,4,5,6,7,8,8α-octahydroazulen-5-yl) acrylic acid (rupestonic acid) amide derivatives and in vitro inhibitive activities against influenza A3,B and herpes simplex type 1 and 2 virus. Bull Korean Chem Soc 2009; 30(2): 435-40.
[http://dx.doi.org/10.5012/bkcs.2009.30.2.435]
[45]
Yong JP, Aisa HA. Synthesis of rupestonic acid amide derivatives and in vitro anti-influenza A3, B and herpes simplex type 1 and 2 viruses. Chem Nat Compd 2008; 44(3): 311-4.
[http://dx.doi.org/10.1007/s10600-008-9050-y]
[46]
Yong JP, Aisa HA. Synthesis of rupestonic acid amide derivatives and in vitro anti-influenza A3, B and herpes simplex type I and II viruses. Youji Huaxue 2008; 28(10): 1807-12.
[47]
Yong JP, Aisa HA, Nie LF. Synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type I and II viruses. Youji Huaxue 2009; 29(10): 1640-4.
[48]
Yong JP, Aisa HA. Chemical modification of rupestonic acid and preliminarily in vitro antiviral activity against influenza A3 and B viruses. Bull Korean Chem Soc 2011; 32(4): 1293-7.
[http://dx.doi.org/10.5012/bkcs.2011.32.4.1293]
[49]
Yong JP, Zhao JY, Aisa HA. Synthesis of 3-deoxyrupestonic acid and its activity against flu virus in vitro. Shizhen Guo Yi Guo Yao 2011; 22(1): 19-21.
[50]
Yong JP, Lu CZ. Rupestonic acid and ephedrine derivatives, preparation and use Chinese Patent 2,022,101,355,161, 2022.
[51]
Yong JP. Synthesis of rupestonic acid derivatives and in vitro inhibition against influenza and herpes simplex viral activities. PhD Thesis, The University of Chinese Academy of Sciences: Beijing, December 2008.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy