Title:Time-restricted Feeding Changes as Inspiration for Drug Design
Volume: 29
Issue: 8
Author(s): Zhangyuting He, Huayu Yang and Yilei Mao*
Affiliation:
- Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences
(CAMS), 100730, Beijing, China
Keywords:
Drug design, glucose metabolism, metabolic syndrome, time-restricted feeding, melatonin, agomelatine.
Abstract: Time-restricted feeding (TRF) is a special lifestyle intervention that improves glucose metabolism,
regulates lipid metabolism, increases gut micro richness, and strengthens circadian rhythm. Diabetes is a
remarkable component of metabolic syndrome, and individuals with diabetes can benefit from TRF. Melatonin
and agomelatine can strengthen circadian rhythm, which is a crucial mechanism of TRF. New drug designs can
be inspired by the related mechanisms and influences of TRF on glucose metabolism, and more researches are
needed to clarify the specific diet-related mechanisms and apply this knowledge to further drug design.