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Review Article

长链非编码rna依赖性调节心力衰竭和心脏肥厚的新见解:从分子功能到诊断和治疗

卷 31, 期 11, 2024

发表于: 15 May, 2023

页: [1404 - 1426] 页: 23

弟呕挨: 10.2174/0929867330666230306143351

价格: $65

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摘要

心力衰竭(HF)是一个公共卫生问题，给医疗保健系统带来了高昂的成本。尽管心衰的治疗和预防取得了重大进展，但它仍然是世界范围内发病率和死亡率的主要原因。目前的临床诊断或预后生物标志物，以及治疗策略，有一些局限性。遗传和表观遗传因素已被确定为心衰发病机制的核心。因此，它们可能为心衰提供新的诊断和治疗方法。长链非编码RNA (Long non-coding RNA, lncRNAs)是一类由RNA聚合酶II产生的RNA。这些分子在不同的细胞生物学过程中发挥重要作用，如转录和基因表达调节。LncRNAs可以通过靶向生物分子或多种不同的细胞机制影响不同的信号通路。在包括心衰在内的不同类型的心血管疾病中，已经报道了它们表达的改变，这支持了它们在心脏病的发生和进展中起重要作用的理论。因此，这些分子可以作为心衰的诊断、预后和治疗生物标志物。在这篇综述中，我们总结了不同的lncrna作为心衰的诊断、预后和治疗生物标志物。此外，我们强调了HF中不同lncrna失调的各种分子机制。

关键词: 心力衰竭，长链非编码RNA, microRNA，分子机制，生物标志物，呼吸困难。

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