A Comprehensive Review on the Anti-inflammatory Activity of Chalconesderived
Moieties

Roopal      Mittal; Shailesh      Sharma; Ajay   Singh   Kushwah; Obaid      Yaqoob; Deepika      Kumari

doi:10.2174/2215083809666230301085620

Abstract

Background: In recent decades, all-embracing research accounting for thousands of natural bioactive compounds have been detailed on behalf of their origin, pharmacological activity, active phytoconstituents, and therapeutic applications. Chalcones, secondary metabolites have shown therapeutic potential against various forms of inflammation, pain, and cancer in multiple research papers targeting their pathway inhibition and their significant therapeutic activity.

Area Covered: Diverse aspects of chalcones have been focused on with their biological source, pathway inhibition, and pharmacological activity.

Objectives: This study aims to focus on the chalcones being the origin of ethnopharmacological, possess extensive pharmacological activities, including anti-neoplastic, antimicrobial, anti-inflammatory, antioxidant, anti-acne, anti-aging, hepatoprotective, neuroprotective, psychoactive, anti-parasitic, and many others.

Methods: Chalcones display anti-inflammatory activity via COX-2, NO synthase, and TNF-α inhibition. Furthermore, comprehensive studies will be discussed with a viewpoint of the chalcones’s role in the alleviation of inflammation. According to recent advancements, chalcones clinically have been used in the treatment of inflammation, anti-aging, oxidative stress reduction, autophagy, and apoptosis.

Conclusion: This article focuses on the molecular progression of inflammation and the chalcone role in combating inflammation by targeting inflammatory mediators and pathways.

Keywords: Nrf2/NF-κB signals, physiochemical properties, inflammation, natural chalcones, narigenin, cardomonin.

Graphical Abstract

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DOI https://dx.doi.org/10.2174/2215083809666230301085620	Print ISSN 2215-0838
Publisher Name Bentham Science Publisher	Online ISSN 2215-0846

Current Traditional Medicine

A Comprehensive Review on the Anti-inflammatory Activity of Chalconesderived Moieties

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Integrating Herbal Medicine into Modern Healthcare: An Evidence-Based Perspective

Current Traditional Medicine

A Comprehensive Review on the Anti-inflammatory Activity of Chalconesderived Moieties

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Call for Papers in Thematic Issues

Integrating Herbal Medicine into Modern Healthcare: An Evidence-Based Perspective

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