摘要
迄今为止,众所周知,许多心血管起源疾病(冠心病、心肌梗死、心肌病、Takotsubo综合征、心力衰竭等)和心外起源疾病(肾衰竭、慢性阻塞性肺病、败血症、糖尿病等)会对心肌的收缩细胞(心肌细胞)造成损伤。证明心肌细胞损伤的最敏感和最具体的标准是心肌特异性肌钙蛋白(CSTns)-CSTnI和CSTnT。根据欧洲、美国和俄罗斯心脏病学会目前的临床建议,CSTnI和CSTnT是心肌梗死早期诊断的主要生物标志物。高血压是心血管疾病发展的最危险和最常见的风险因素之一,并与危险的心血管并发症的高风险相关。因此,迫切需要寻找新的生物标志物来及时评估高血压患者的预后。这篇小型综述旨在证实使用心脏标志物(CSTnI和CSTnT)评估高血压患者预后的可能性,并讨论导致心肌细胞损伤和血清CSTnI、CSTnT水平升高的潜在机制。这是一篇叙述性的小型综述,使用以下数据库编制:Pubmed/Medline、Pubmed Central、Embase、Scopus和Web of Science。文献检索中使用了以下关键词:“心肌细胞”、“损伤”、“损害”和“高血压”,并结合术语“损伤机制”、“预测意义”、“心肌肌钙蛋白”或“心肌特异性肌钙蛋白”。
关键词: 心肌细胞,损伤,损伤机制,心血管疾病,高血压,血压,心肌特异性肌钙蛋白,高灵敏度,预测意义。
[http://dx.doi.org/10.17305/bjbms.2003.3527] [PMID: 16232149]
[http://dx.doi.org/10.1016/j.amjmed.2013.03.003] [PMID: 23764266]
[http://dx.doi.org/10.1093/eurheartj/ehaa575] [PMID: 32860058]
[http://dx.doi.org/10.2147/VHRM.S300002] [PMID: 34113117]
[http://dx.doi.org/10.1007/s10974-019-09513-1] [PMID: 31030382]
[http://dx.doi.org/10.2174/1573403X18666220413124038] [PMID: 35422225]
[http://dx.doi.org/10.1155/2010/350706] [PMID: 20617149]
[http://dx.doi.org/10.1016/j.cjca.2015.06.015] [PMID: 26440512]
[http://dx.doi.org/10.1016/j.abb.2016.02.004] [PMID: 26851561]
[http://dx.doi.org/10.1085/jgp.202012815] [PMID: 33492345]
[http://dx.doi.org/10.1016/j.gheart.2018.08.004] [PMID: 30154043]
[http://dx.doi.org/10.15829/29/1560-4071-2020-4103]
[http://dx.doi.org/10.15829/1560-4071-2021-4449]
[http://dx.doi.org/10.1186/1471-2369-14-229] [PMID: 24148285]
[http://dx.doi.org/10.15829/1728-8800-2021-2539]
[http://dx.doi.org/10.1007/s00063-015-0116-x] [PMID: 26564181]
[http://dx.doi.org/10.1007/s12265-020-10042-3] [PMID: 32642841]
[http://dx.doi.org/10.17802/2306-1278-2020-9-3-69-80]
[http://dx.doi.org/10.20996/1819-6446-2022-02-11]
[http://dx.doi.org/10.1016/j.jacc.2018.07.067] [PMID: 30286920]
[http://dx.doi.org/10.3390/life11111175] [PMID: 34833051]
[http://dx.doi.org/10.1373/clinchem.2016.261495] [PMID: 28062620]
[http://dx.doi.org/10.3390/ijms222010928] [PMID: 34681585]
[http://dx.doi.org/10.1002/clc.23337] [PMID: 31975465]
[http://dx.doi.org/10.3390/life11090914] [PMID: 34575063]
[http://dx.doi.org/10.1007/s11739-013-1030-y] [PMID: 24326466]
[http://dx.doi.org/10.14529/hsm220202]
[http://dx.doi.org/10.1016/j.jacc.2013.05.070] [PMID: 23810896]
[http://dx.doi.org/10.5867/medwave.2021.11.002132] [PMID: 34890387]
[http://dx.doi.org/10.2459/JCM.0000000000000811] [PMID: 31259857]
[http://dx.doi.org/10.15829/1560-4071-2020-4061]
[http://dx.doi.org/10.1016/j.ijcard.2016.06.268] [PMID: 27404692]
[http://dx.doi.org/10.1016/j.cca.2020.02.004] [PMID: 32035091]
[http://dx.doi.org/10.15829/1728-8800-2021-2639]
[http://dx.doi.org/10.1556/650.2022.32296] [PMID: 34974429]
[http://dx.doi.org/10.1016/j.clinbiochem.2021.04.005] [PMID: 33861986]
[http://dx.doi.org/10.1186/s12933-021-01365-9] [PMID: 34419046]
[http://dx.doi.org/10.1016/j.jacc.2017.11.073] [PMID: 29495991]
[http://dx.doi.org/10.35772/ghm.2021.01025] [PMID: 33937572]
[http://dx.doi.org/10.1016/j.peptides.2014.04.002] [PMID: 24747283]
[PMID: 24521627]
[http://dx.doi.org/10.18087/cardio.2019.11.n414] [PMID: 31849301]
[http://dx.doi.org/10.3390/jcm9123917] [PMID: 33276667]
[PMID: 28501835]
[http://dx.doi.org/10.15829/1560-4071-2020-3814]
[http://dx.doi.org/10.1093/eurheartj/ehy339] [PMID: 30165516]
[http://dx.doi.org/10.1016/S0140-6736(16)31919-5] [PMID: 27863813]
[http://dx.doi.org/10.3390/cells11193157] [PMID: 36231118]
[http://dx.doi.org/10.1016/S0140-6736(05)17741-1] [PMID: 15652604]
[http://dx.doi.org/10.2147/IBPC.S223341] [PMID: 33173330]
[http://dx.doi.org/10.1016/j.trsl.2021.08.003] [PMID: 34411778]
[http://dx.doi.org/10.1093/ajh/hpw136] [PMID: 28057629]
[http://dx.doi.org/10.1016/j.ajem.2015.09.037] [PMID: 26508391]
[http://dx.doi.org/10.3109/08037051.2013.840429] [PMID: 24059745]
[http://dx.doi.org/10.1111/j.1751-7176.2011.00476.x] [PMID: 21806764]
[http://dx.doi.org/10.22514/SV133.062017.13]
[http://dx.doi.org/10.23736/S1825-859X.21.00107-9]
[http://dx.doi.org/10.1016/j.mehy.2020.110252] [PMID: 33254557]
[http://dx.doi.org/10.1152/physiol.00015.2016] [PMID: 27927803]
[http://dx.doi.org/10.1126/science.1164680] [PMID: 19342590]
[http://dx.doi.org/10.17802/2306-1278-2019-8-4-103-115]
[http://dx.doi.org/10.1016/j.jacc.2013.12.032] [PMID: 24530665]
[http://dx.doi.org/10.1016/j.clinbiochem.2019.11.013] [PMID: 31786204]
[http://dx.doi.org/10.15829/1728-8800-2021-2590]
[http://dx.doi.org/10.1016/j.amjmed.2008.08.033] [PMID: 19114174]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014364] [PMID: 26152706]
[http://dx.doi.org/10.1007/s00467-009-1165-2] [PMID: 19444486]
[http://dx.doi.org/10.1172/JCI118280] [PMID: 7593611]
[http://dx.doi.org/10.1016/j.jacc.2018.04.029] [PMID: 29929614]
[http://dx.doi.org/10.1371/journal.pone.0196626] [PMID: 29709009]
[http://dx.doi.org/10.1002/jcp.10024] [PMID: 11748583]
[http://dx.doi.org/10.31684/2542-1336.2019.1(13).52-56]
[http://dx.doi.org/10.15275/rusomj.2020.0305]
[http://dx.doi.org/10.1007/s00392-017-1152-8] [PMID: 28856443]
[http://dx.doi.org/10.1136/hrt.2010.212621] [PMID: 21525526]
[http://dx.doi.org/10.21103/Article10(3)_RA3]
[http://dx.doi.org/10.22514/sv.2021.050]
[http://dx.doi.org/10.1161/01.CIR.96.1.19] [PMID: 9236409]
[http://dx.doi.org/10.1055/s-0029-1214145] [PMID: 19308890]
[http://dx.doi.org/10.33678/cor.2021.041]
[http://dx.doi.org/10.33396/1728-0869-2017-1-25-33]
[http://dx.doi.org/10.18087/cardio.2506] [PMID: 30990149]
[http://dx.doi.org/10.15275/rusomj.2021.0311]
[http://dx.doi.org/10.2174/0929867329666220610200409] [PMID: 35702777]
[http://dx.doi.org/10.1007/s00424-007-0354-8] [PMID: 17909848]
[http://dx.doi.org/10.21103/Article11(3)_RA2]
[http://dx.doi.org/10.1016/j.yjmcc.2013.07.004] [PMID: 23871791]
[PMID: 31535507]
[http://dx.doi.org/10.1016/j.ajem.2019.11.041] [PMID: 31831340]
[http://dx.doi.org/10.1007/978-94-017-9523-4_4] [PMID: 25355567]
[http://dx.doi.org/10.1016/j.legalmed.2009.01.005] [PMID: 19251459]
[http://dx.doi.org/10.1016/j.legalmed.2011.05.002] [PMID: 21683643]
[http://dx.doi.org/10.5336/cardiosci.2021-84307]
[http://dx.doi.org/10.1373/clinchem.2016.266635] [PMID: 28428352]
[http://dx.doi.org/10.1038/jhh.2012.53] [PMID: 23254594]
[http://dx.doi.org/10.1016/j.cpcardiol.2021.101067] [PMID: 34826431]
[http://dx.doi.org/10.2174/0929867323666161004150857] [PMID: 27719655]
[http://dx.doi.org/10.1155/2022/6454467] [PMID: 35402607]
[http://dx.doi.org/10.5603/KP.a2016.0097] [PMID: 27296284]
[http://dx.doi.org/10.15829/1560-4071-2020-4140]
[http://dx.doi.org/10.7759/cureus.6787] [PMID: 32140347]
[http://dx.doi.org/10.1097/HJH.0b013e3283599b4f] [PMID: 22990357]
[http://dx.doi.org/10.2174/1573403X18666220817103105] [PMID: 35980071]
[http://dx.doi.org/10.2147/VHRM.S315376] [PMID: 34366667]
[http://dx.doi.org/10.1016/j.amjmed.2018.11.017] [PMID: 30503877]