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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease

Author(s): Shao Ouyang, Zhi-Xiang Zhou, Hui-Ting Liu, Zhong Ren, Huan Liu, Nian-Hua Deng, Kai-Jiang Tian, Kun Zhou, Hai-lin Xie and Zhi-Sheng Jiang*

Volume 31, Issue 10, 2024

Published on: 22 March, 2023

Page: [1251 - 1264] Pages: 14

DOI: 10.2174/0929867330666230213100732

Price: $65

Abstract

Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets for the diagnosis and drug therapy of CAD.

Keywords: Long noncoding RNAs, endothelial cells, coronary atherosclerotic heart disease, diagnosis, drug therapy, smooth muscle cell.

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