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Review Article

LncRNA介导的内皮细胞调控：冠状动脉粥样硬化发病机制的新进展

卷 31, 期 10, 2024

发表于: 22 March, 2023

页: [1251 - 1264] 页: 14

弟呕挨: 10.2174/0929867330666230213100732

价格: $65

Open Access Journals Promotions 2
摘要

冠状动脉粥样硬化性疾病（CAD）是一种常见的心血管疾病，也是导致死亡的重要原因。此外，内皮细胞（EC）损伤是CAD的早期病理生理特征，并且长链非编码RNA（lncRNA）可以调节基因表达。最近的研究表明lncRNA参与CAD的发病机制，尤其是通过调节内皮细胞。在这篇综述中，我们总结了lncRNA调节的内皮细胞在CAD发病机制中的新进展，包括内皮细胞增殖、迁移、粘附、血管生成、炎症、细胞凋亡、自噬和pyroptosis。因此，由于lncRNA调节CAD中的内皮细胞，lncRNA将为CAD的诊断和药物治疗提供理想和新的靶点。

关键词: 长链非编码RNA，内皮细胞，冠状动脉粥样硬化性心脏病，诊断，药物治疗，平滑肌细胞。

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