Title:Apolipoprotein A-1 as a Potential Biomarker for Solid Tumors: A
Systematic Review and Meta-Analysis
Volume: 30
Issue: 29
关键词:
载脂蛋白A-I（ApoA-1），癌症，血清，尿液，诊断，生物标志物。
摘要:
Background: The diagnostic value of apolipoprotein A-I (ApoA-I) as a marker
of different malignancies has been reported in several investigations; however, the results
have been contradictory. The current meta-analysis examined the association between
ApoA-I levels and human malignancies.
Methods: We reviewed the databases and retrieved papers for analysis until November
1st, 2021. Random-effects meta-analysis was performed to construct the pooled diagnostic
parameters. To find the causes of heterogeneity, we utilized Spearman threshold effect
analysis and subgroup analysis. The I2 and Chi-square tests were used to examine the
heterogeneity. Moreover, subgroup analyses were performed based on sample type
(serum/urine) and geographical region of study. Finally, publication bias was explored using
Begg's and Egger’s tests.
Results: A total of 11 articles involving 4,121 participants (2,430 cases and 1,691 controls)
were included. The overall pooled sensitivity, specificity, positive likelihood ratio (PLR),
negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the
curve (AUC) were 0.764 (95% CI: 0.746 - 0.781), 0.795 (95% CI: 0.775 - 0.814), 5.105
(95% CI: 3.313 - 7.865), 0.251 (95% CI: 0.174 - 0.364), 24.61 (95% CI: 12.22 - 49.54),
and 0.93, respectively. In subgroup analyses, better diagnostic values were found for
urine samples and East Asian Countries (China, Korea, and Taiwan).
Conclusion: Urinary ApoA-I levels may serve as a favorable diagnostic marker for cancer.
