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Current Medicinal Chemistry

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Review Article

LncRNA PVT1 as a Novel Biomarker for Diabetes-related Complications

Author(s): Xinyan Qiu, Jinlan Chen, Jingjie Yang, Jiahui Hu, Peng Fan* and Chengfu Yuan*

Volume 31, Issue 6, 2024

Published on: 08 March, 2023

Page: [688 - 696] Pages: 9

DOI: 10.2174/0929867330666230210103447

Price: $65

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Abstract

Diabetes is now afflicting an expanding population, and it has become a major source of concern for human health. Diabetes affects several organs and causes chronic damage and dysfunction. It is one of the three major diseases that are harmful to human health. Plasmacytoma variant translocation 1 is a member of long non-coding RNA. PVT1 expression profile abnormalities have been reported in diabetes mellitus and its consequences in recent years, suggesting that it may contribute to the disease's progression. Relevant literature from the authoritative database “PubMed” are retrieved and summarized in detail. Mounting evidence reveals that PVT1 has multiple functions. Through sponge miRNA, it can participate in a wide variety of signal pathways and regulate the expression of a target gene. More importantly, PVT1 is crucially implicated in the regulation of apoptosis, inflammation, and so on in different types of diabetes-related complications. PVT1 regulates the occurrence and progression of diabetes-related diseases. Collectively, PVT1 has the potential to be a useful diagnostic and therapeutic target for diabetes and its consequences.

Keywords: Diabetes mellitus, diabetes-related complications, long non-coding RNA, PVT1, insulin, biomarker.

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