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Abstract
Apolipoprotein E4 (APOE4) is one of the primary genetic risk factors for late-onset of Alzheimer's disease (AD). While its primary function is to transport cholesterol, it also regulates metabolism, aggregation, and deposition of amyloid-β (Aβ) in the brain. The disruption in the generation and removal of Aβ in the brain is the primary cause of memory and cognitive loss and thus plays a significant role in the development of AD. In several prior genetic investigations, the APOE4 allele has been linked to higher susceptibility to severe acute respiratory syndrome (SARSCoV- 2) infection and COVID-19 mortality. However, information on the involvement of APOE4 in the underlying pathology and clinical symptoms is limited. Due to the high infection and mortality rate of COVID-19 in AD individuals, challenges have been identified in the management of AD patients during the COVID-19 pandemic. In order to provide evidence-based, more effective healthcare, it is critical to identify underlying concerns and, preferably, biomarkers. The risk variant APOE4 imparts enhanced infectivity by the underlying coronavirus SARS-CoV-2 at a cellular level, genetic level, and route level. Here we review existing advances in clinical and basic research on the AD-related gene APOE, as well as the role of APOE in AD pathogenesis, using neurobiological evidence. Moreover, the role of APOE in severe COVID-19 in Alzheimer's patients has also been reviewed.
Keywords: APOE4, apolipoprotein, alzheimer, COVID-19, amyloid-β, SARS-CoV-2.
[http://dx.doi.org/10.2174/1389201022666210127113441] [PMID: 33504302]
[http://dx.doi.org/10.1080/15321819.2021.1904414] [PMID: 33788668]
[http://dx.doi.org/10.1080/22221751.2021.1898291] [PMID: 33666147]
[http://dx.doi.org/10.1016/j.peptides.2021.170583] [PMID: 34087220]
[http://dx.doi.org/10.1002/cmdc.202100079] [PMID: 33811458]
[http://dx.doi.org/10.1080/15321819.2021.1951291] [PMID: 34355645]
[http://dx.doi.org/10.2174/1872208316666220124101611] [PMID: 35068398]
[http://dx.doi.org/10.1038/s41579-021-00535-6] [PMID: 33753932]
[http://dx.doi.org/10.1128/mBio.01140-21] [PMID: 34465019]
[http://dx.doi.org/10.1038/s41586-021-03710-0] [PMID: 34153974]
[http://dx.doi.org/10.1007/s00415-021-10406-y] [PMID: 33486564]
[http://dx.doi.org/10.1016/j.jneuroim.2021.577658] [PMID: 34304141]
[http://dx.doi.org/10.3389/fimmu.2020.621735] [PMID: 33584720]
[http://dx.doi.org/10.1001/jamaneurol.2020.2065] [PMID: 32469387]
[http://dx.doi.org/10.3906/biy-2106-23] [PMID: 34803439]
[http://dx.doi.org/10.3389/fneur.2020.00518] [PMID: 32574248]
[http://dx.doi.org/10.1007/s12640-021-00389-z] [PMID: 34169404]
[http://dx.doi.org/10.1007/s12028-020-00978-4] [PMID: 32346843]
[http://dx.doi.org/10.3233/JAD-210335] [PMID: 34092646]
[http://dx.doi.org/10.1016/j.jneuroim.2020.577436] [PMID: 33212316]
[http://dx.doi.org/10.1007/s12031-020-01767-6] [PMID: 33464535]
[http://dx.doi.org/10.1007/s10238-020-00648-x] [PMID: 32720223]
[http://dx.doi.org/10.1007/s11033-021-06520-9] [PMID: 34232464]
[http://dx.doi.org/10.1111/jsr.13229] [PMID: 33289311]
[http://dx.doi.org/10.1007/s12017-009-8104-z] [PMID: 20232515]
[http://dx.doi.org/10.2174/1386207325666211122123602] [PMID: 34809541]
[http://dx.doi.org/10.1038/aps.2017.28] [PMID: 28713158]
[http://dx.doi.org/10.1038/nrneurol.2015.119] [PMID: 26195256]
[http://dx.doi.org/10.1021/acschemneuro.8b00627] [PMID: 30609357]
[http://dx.doi.org/10.3389/fnagi.2016.00160] [PMID: 27458370]
[http://dx.doi.org/10.1016/j.atherosclerosis.2021.05.007] [PMID: 34058468]
[http://dx.doi.org/10.3390/genes12111768] [PMID: 34828374]
[http://dx.doi.org/10.1038/s41467-021-23762-0] [PMID: 34099706]
[http://dx.doi.org/10.1002/glia.23974] [PMID: 33556209]
[http://dx.doi.org/10.1016/j.conb.2021.02.001] [PMID: 33647674]
[http://dx.doi.org/10.1126/sciadv.abm6668] [PMID: 36129973]
[http://dx.doi.org/10.1186/s40478-021-01302-7] [PMID: 34949230]
[http://dx.doi.org/10.1038/s41586-022-05344-2] [PMID: 36130725]
[http://dx.doi.org/10.1038/s41580-021-00418-x] [PMID: 34611326]
[http://dx.doi.org/10.1093/gerona/glaa200] [PMID: 32777042]
[http://dx.doi.org/10.1159/000516200] [PMID: 33965962]
[http://dx.doi.org/10.1007/s11883-020-00896-y] [PMID: 33006059]
[http://dx.doi.org/10.1093/gerona/glaa131] [PMID: 32451547]
[http://dx.doi.org/10.1016/j.stem.2020.12.018] [PMID: 33450186]
[http://dx.doi.org/10.1186/s13195-021-00858-9] [PMID: 34118974]
[http://dx.doi.org/10.1186/s13195-020-00744-w] [PMID: 33380345]
[http://dx.doi.org/10.1194/jlr.R800058-JLR200] [PMID: 19018038]
[http://dx.doi.org/10.1016/S1474-4422(20)30412-9] [PMID: 33340485]
[http://dx.doi.org/10.3389/fimmu.2020.01939] [PMID: 33042114]
[http://dx.doi.org/10.1016/j.redox.2021.101938] [PMID: 33730676]
[http://dx.doi.org/10.1177/1533317513481097] [PMID: 23612909]
[http://dx.doi.org/10.3389/fnagi.2019.00014] [PMID: 30804776]
[http://dx.doi.org/10.3389/fimmu.2020.00754] [PMID: 32425941]
[http://dx.doi.org/10.1186/s13024-020-0358-9] [PMID: 32005122]
[http://dx.doi.org/10.1016/j.stemcr.2019.08.004] [PMID: 31522977]
[http://dx.doi.org/10.1016/j.neuron.2014.01.045] [PMID: 24559670]
[http://dx.doi.org/10.1038/s41467-019-10192-2] [PMID: 31133680]
[http://dx.doi.org/10.1007/s12035-018-1237-z] [PMID: 30032423]
[http://dx.doi.org/10.3390/nu13041362] [PMID: 33921683]
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