Title:A Systematic Review on Traumatic Brain Injury Pathophysiology and
Role of Herbal Medicines in its Management
Volume: 21
Issue: 12
Author(s): Kaushal Arora, Vishal Vats, Nalin Kaushik, Deepanshu Sindhawani, Vaishali Saini, Divy Mohan Arora, Yogesh Kumar, Etash Vashisht, Govind Singh and Prabhakar Kumar Verma*
Affiliation:
- Department of Pharmaceutical Sciences Maharshi Dayanand University, Rohtak, Haryana, 124001, India
Keywords:
Traumatic brain injury, medicinal herbal plants, neurodegenerative disorder, pathophysiology, inflammation, oxidative stress, glucose metabolism.
Abstract:
Background: Traumatic brain injury (TBI) is a worldwide problem. Almost about sixtynine
million people sustain TBI each year all over the world. Repetitive TBI linked with increased risk
of neurodegenerative disorder such as Parkinson, Alzheimer, traumatic encephalopathy. TBI is characterized
by primary and secondary injury and exerts a severe impact on cognitive, behavioral, psychological
and other health problem. There were various proposed mechanism to understand complex
pathophysiology of TBI but still there is a need to explore more about TBI pathophysiology. There are
drugs present for the treatment of TBI in the market but there is still need of more drugs to develop for
better and effective treatment of TBI, because no single drug is available which reduces the further
progression of this injury.
Objective: The main aim and objective of structuring this manuscript is to design, develop and gather
detailed data regarding about the pathophysiology of TBI and role of medicinal plants in its treatment.
Method: This study is a systematic review conducted between January 1995 to June 2021 in which a
consultation of scientific articles from indexed periodicals was carried out in Science Direct, United
States National Library of Medicine (Pubmed), Google Scholar, Elsvier, Springer and Bentham.
Results: A total of 54 studies were analyzed, on the basis of literature survey in the research area of TBI.
Conclusion: Recent studies have shown the potential of medicinal plants and their chemical constituents
against TBI therefore, this review targets the detailed information about the pathophysiology of
TBI and role of medicinal plants in its treatment.