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Review Article

硫化氢(H2S):一种有效的癌症调节剂和治疗前药

卷 30, 期 40, 2023

发表于: 03 March, 2023

页: [4506 - 4532] 页: 27

弟呕挨: 10.2174/0929867330666230126100638

价格: $65

摘要

硫化氢(H2S)是一种存在于所有生物体内的内源性气体分子，传统上对其毒性进行了研究。有趣的是，最近对H2S在器官生理学中的作用的进一步了解表明它作为一种信号分子的相关性，在包括癌症在内的各种临床疾病中具有潜在的重要意义。H2S主要在哺乳动物细胞中通过多种酶促途径产生，其生物学机制和治疗作用的研究也越来越深入。在此，我们描述了H2S的生理生化特性，导致其内源性生产的酶途径及其分解代谢途径。此外，我们还讨论了目前已知的H2S释放剂或H2S供体的作用，包括它们作为治疗工具的潜力。然后，我们说明了已知的支持H2S多效效应的机制，特别关注过氧化氢，过氧化氢在H2S介导的信号通路中起关键作用。然后，我们讨论了H2S在肿瘤生物学中发挥的矛盾作用，并讨论了利用H2S水平作为新型癌症生物标志物和诊断工具的潜力。最后，我们描述了最近的临床前应用，重点是评估最常见的硫化氢释放化合物的抗癌作用。虽然支持H2S在转化医学领域作为替代癌症治疗的证据尚未明确提供，但H2S在临床前试验中的应用正在成为一种有效的抗癌治疗方法。

关键词: 硫化氢，抗肿瘤，抗癌，癌症生物标志物，硫化氢供体和临床前试验，治疗前药。

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