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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Biography

Meet the Editorial Board Member

Author(s): Peng Zhan

Volume 30, Issue 40, 2023

Published on: 01 June, 2023

Page: [4505 - 4505] Pages: 1

DOI: 10.2174/092986733040230601154409

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[1]
Zhao, T.; Meng, Q.; Sun, Z.; Chen, Y.; Ai, W.; Zhao, Z.; Kang, D.; Dong, Y.; Liang, R.; Wu, T.; Pang, J.; Liu, X.; Zhan, P. Novel human urate transporter 1 inhibitors as hypouricemic drug candidates with favorable druggability. J. Med. Chem., 2020, 63(19), 10829-10854.
[http://dx.doi.org/10.1021/acs.jmedchem.0c00223] [PMID: 32897699]
[2]
Xiu, S.; Dick, A.; Ju, H.; Mirzaie, S.; Abdi, F.; Cocklin, S.; Zhan, P.; Liu, X. Inhibitors of SARS-CoV-2 entry: current and future opportunities. J. Med. Chem., 2020, 63(21), 12256-12274.
[http://dx.doi.org/10.1021/acs.jmedchem.0c00502] [PMID: 32539378]
[3]
Sun, L.; Dick, A.; Meuser, M.E.; Huang, T.; Zalloum, W.A.; Chen, C.H.; Cherukupalli, S.; Xu, S.; Ding, X.; Gao, P.; Kang, D.; De Clercq, E.; Pannecouque, C.; Cocklin, S.; Lee, K.H.; Liu, X.; Zhan, P. Design, synthesis, and mechanism study of benzenesulfonamide-containing phenylalanine derivatives as novel HIV-1 capsid inhibitors with improved antiviral activities. J. Med. Chem., 2020, 63(9), 4790-4810.
[http://dx.doi.org/10.1021/acs.jmedchem.0c00015] [PMID: 32298111]
[4]
Kang, D.; Feng, D.; Sun, Y.; Fang, Z.; Wei, F.; De Clercq, E.; Pannecouque, C.; Liu, X.; Zhan, P. Structure-based bioisosterism yields HIV-1 NNRTIs with improved drug-resistance profiles and favorable pharmacokinetic properties. J. Med. Chem., 2020, 63(9), 4837-4848.
[http://dx.doi.org/10.1021/acs.jmedchem.0c00117] [PMID: 32293182]
[5]
Kang, D.; Ruiz, F.X.; Feng, D.; Pilch, A.; Zhao, T.; Wei, F.; Wang, Z.; Sun, Y.; Fang, Z.; De Clercq, E.; Pannecouque, C.; Arnold, E.; Liu, X.; Zhan, P. Discovery and characterization of fluorine-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs with highly improved resistance profiles and low activity for the hERG ion channel. J. Med. Chem., 2020, 63(3), 1298-1312.
[http://dx.doi.org/10.1021/acs.jmedchem.9b01769] [PMID: 31935327]
[6]
Wu, G.; Zhao, T.; Kang, D.; Zhang, J.; Song, Y.; Namasivayam, V.; Kongsted, J.; Pannecouque, C.; De Clercq, E.; Poongavanam, V.; Liu, X.; Zhan, P. Overview of recent strategic advances in medicinal chemistry. J. Med. Chem., 2019, 62(21), 9375-9414.
[http://dx.doi.org/10.1021/acs.jmedchem.9b00359] [PMID: 31050421]
[7]
Zhan, P.; Kang, D.; Liu, X. Resurrecting the condemned: identification of n-benzoxaborole benzofuran GSK8175 as a clinical candidate with reduced metabolic liability. J. Med. Chem., 2019, 62(7), 3251-3253.
[http://dx.doi.org/10.1021/acs.jmedchem.9b00415] [PMID: 30916967]
[8]
Huang, B.; Chen, W.; Zhao, T.; Li, Z.; Jiang, X.; Ginex, T.; Vílchez, D.; Luque, F.J.; Kang, D.; Gao, P.; Zhang, J.; Tian, Y.; Daelemans, D.; De Clercq, E.; Pannecouque, C.; Zhan, P.; Liu, X. Exploiting the tolerant region i of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket: discovery of potent diarylpyrimidine-typed HIV-1 NNRTIs against wild-type and E138K mutant virus with significantly improved water solubility and favorable safety profiles. J. Med. Chem., 2019, 62(4), 2083-2098.
[http://dx.doi.org/10.1021/acs.jmedchem.8b01729] [PMID: 30721060]

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