Title:Novel 1,4-Dihydropyrido[2,3-B]Pyrazine-2,3-Dione Derivatives for Treating Cancer
and Other Disorders Associated with KRAS Activity
Volume: 23
Issue: 8
Author(s): Surya K. De*
Affiliation:
- Department of Chemistry, Institute of Conju-probe, San Diego, California, USA
- Department of Chemistry, Bharath University,
Chennai, Tamil Nadu, 600126, India
Keywords:
KRAS mutant, covalent inhibitor, bicyclic dione compounds, NRAS, HRAS, cancer.
Abstract: This application describes the synthesis of new 1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione derivatives and
methods of using these compounds as KRAS covalent inhibitors. This class of compounds is useful for treating cancer
and other diseases associated with KRAS activity.