Identification of a Peptide Binding To the Hiv-1 Nucleocapsid Protein (Ncp7)

Title:Identification of a Peptide Binding To the Hiv-1 Nucleocapsid Protein (Ncp7)

Volume: 3 Issue: 6

Author(s): Raffaele A. Calogero*, Daniela Lener, Gianni Antico, Rosanna del Gaudio, Anna Aulicino and Giuseppe Geraci

Affiliation:

• Dipartimento di Genetica, Biologia Generale e Molecolare, via Mezzocannone 8, 80134 Napoli, Italy

Abstract: In HIV-1 the nucleocapsid protein (NC) is essential in the virion assembly process. The discovery of substances able to interfere with the HIV-1 NC functions could be a starting point for the design of new drugs that might inhibit the HIV-1 viral infectivity. A single peptide sequence binding to the NC was isolated using a conformationally homogeneous phage displayed-peptide library. The minimal requirement for the NCp7/peptide interaction was the NCp7 region encompassing the second zinc finger.

Cite this article as:

Calogero A. Raffaele*, Lener Daniela, Antico Gianni, del Gaudio Rosanna, Aulicino Anna and Geraci Giuseppe, Identification of a Peptide Binding To the Hiv-1 Nucleocapsid Protein (Ncp7), Protein & Peptide Letters 1996; 3 (6) . https://dx.doi.org/10.2174/092986650306221101112554