Abstract
Peptides from Herpes Simplex virus type I glycoprotein-D,containing the Asp-Pro bond were synthesised by SPPS using benzyl or cyclohexyl (cHex) protection at the Asp/Glu side chains. Increased stability of the cHex group was demonstrated during the treatment with TMSOTf-thioanisole/TFA. This observation was successfully utilised to prepare partly protected 9-mer peptides and their 18-mer derivatives by fragment condensation both in solution and on solid support
Protein & Peptide Letters
Title:Synthesis of Hsv Epitope Peptides with Acid Sensitive Asp-Pro Bond
Volume: 3 Issue: 6
Author(s): Gabor Mezo, Marianna Mak, Szilvia Bosze and Ferene Hudecz*
Affiliation:
- Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest 112, POB 32, H-1518, Hungary
Abstract: Peptides from Herpes Simplex virus type I glycoprotein-D,containing the Asp-Pro bond were synthesised by SPPS using benzyl or cyclohexyl (cHex) protection at the Asp/Glu side chains. Increased stability of the cHex group was demonstrated during the treatment with TMSOTf-thioanisole/TFA. This observation was successfully utilised to prepare partly protected 9-mer peptides and their 18-mer derivatives by fragment condensation both in solution and on solid support
Export Options
About this article
Cite this article as:
Mezo Gabor, Mak Marianna, Bosze Szilvia and Hudecz Ferene*, Synthesis of Hsv Epitope Peptides with Acid Sensitive Asp-Pro Bond, Protein & Peptide Letters 1996; 3 (6) . https://dx.doi.org/10.2174/092986650306221101111128
DOI https://dx.doi.org/10.2174/092986650306221101111128 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers