Synthesis of Hsv Epitope Peptides with Acid Sensitive Asp-Pro Bond

Title:Synthesis of Hsv Epitope Peptides with Acid Sensitive Asp-Pro Bond

Volume: 3 Issue: 6

Author(s): Gabor Mezo, Marianna Mak, Szilvia Bosze and Ferene Hudecz*

Affiliation:

• Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest 112, POB 32, H-1518, Hungary

Abstract: Peptides from Herpes Simplex virus type I glycoprotein-D,containing the Asp-Pro bond were synthesised by SPPS using benzyl or cyclohexyl (cHex) protection at the Asp/Glu side chains. Increased stability of the cHex group was demonstrated during the treatment with TMSOTf-thioanisole/TFA. This observation was successfully utilised to prepare partly protected 9-mer peptides and their 18-mer derivatives by fragment condensation both in solution and on solid support

Cite this article as:

Mezo Gabor, Mak Marianna, Bosze Szilvia and Hudecz Ferene*, Synthesis of Hsv Epitope Peptides with Acid Sensitive Asp-Pro Bond, Protein & Peptide Letters 1996; 3 (6) . https://dx.doi.org/10.2174/092986650306221101111128