Title:Exploration of the Mechanism of Tripterygium Wilfordii in the Treatment
of Myocardial Fibrosis Based on Network Pharmacology and Molecular
Docking
Volume: 19
Issue: 1
Author(s): Yang Ming, Liu Jiachen, Guo Tao and Wang Zhihui*
Affiliation:
- Department of Cardiovascular Medicine, Second Affiliated Hospital of Jilin University, Changchun, China
Keywords:
Tripterygium wilfordii, myocardial fibrosis, network pharmacology, molecular docking, CAD, GO.
Abstract:
Background: A network pharmacology study on the biological action of Tripterygium
wilfordii on myocardial fibrosis (MF).
Methods: The effective components and potential targets of tripterygium wilfordii were screened
from the TCMSP database to develop a combination target network. A protein-protein interaction
network was constructed by analyzing the interaction between tripterygium wilfordii and MF;
then, the Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes
(KEGG) enrichment analysis was performed. Furthermore, molecular docking was utilized to verify
the network analysis results.
Results: It was predicted that MF has 29 components contributing to its effectiveness and 87 potential
targets. It is predicted that Tripterygium wilfordii has 29 active components and 87 potential
targets for the treatment of MF. The principal active components of tripterygium wilfordii include
kaempferol, β-sitosterol, triptolide, and Nobiletin. Signaling pathways: AGE-RAGE, PI3K-Akt,
and MAPK may be involved in the mechanism of its action.7 Seven key targets (TNF, STAT3,
AKT1, TP53, VEGFA, CASP3, STAT1) are possibly involved in treating MF by tripterygium wilfordii.
Conclusion: This study shows the complex network relationship between multiple components,
targets, and pathways of Tripterygium wilfordii in treating MF.
