Title:Flavonoids for the Treatment of Breast Cancer, Present Status and Future Prospective
Volume: 23
Issue: 6
Author(s): Sonali Sahoo, Priyanka Mohapatra and Sanjeeb Kumar Sahoo*
Affiliation:
- Institute of Life Sciences, Nalco Square, Bhubaneswar- 751023, Odisha, India
Keywords:
Breast cancer, flavonoids, apoptosis, tumor microenvironment, metastasis, cell cycle progression.
Abstract: Breast Cancer is one of the most notorious cancer affecting women globally. Current therapies available for
breast cancer treatment have certain limited efficacy; develop drug resistance and severe adverse effects. Thus, identifying
novel therapies for treatment will reduce the devastating effect on cancer survivors. The exhilarating and fastgrowing
studies on flavonoids have evidenced that it has the potential to inflect various antitumor activity and modulate
various signal transduction pathways in carcinogenesis. Flavonoids also have been found to regulate cellular metabolism
and oxidative stress, cell cycle progression, angiogenesis and metastasis, ultimately preventing the progression
of the diseases. As per the reports, a flavonoid-rich diet appears to be the most potent and promising approach to
abate the risk of cancer. Thus, now a day, these are the prime target for drug discovery research. Based on existing
findings, it can be concluded that beyond the currently employed chemotherapeutics, natural products (like flavonoids)
exhibit pleiotropic, multi-target activities and are budding as possible complementary chemopreventive molecules
against breast cancer with fewer side effects than conventional therapy. In this review, we comprehensively highlight
an outline of the multiple pleiotropic pharmacological effects of various major classes of flavonoids on breast cancer
with their specific mechanisms underlying its anticancer effect.