Review Article

心脏疾病的类器官模型:寻找改进心脏再生医学的新途径

卷 30, 期 33, 2023

发表于: 28 December, 2022

页: [3726 - 3742] 页: 17

弟呕挨: 10.2174/0929867330666221021122603

价格: $65

Open Access Journals Promotions 2
摘要

我们正在经历一场再生医学的革命。类器官技术的最新发展为研究人类生物学和疾病提供了独特的机会。事实上,类器官模型通过创建强大的三维(3D)结构来再现初级组织的细胞异质性、结构和功能,彻底改变了生物医学研究的体外培养工具。这种类器官技术使研究人员能够在培养皿中重建人体器官和疾病模型。因此,它在再生医学、药物发现和精准医学等许多转化应用中具有良好的前景。本文综述了目前关于类器官模型的进展和推广的知识,特别是心脏病方法。我们讨论了心脏类器官的临床应用的有用性,并最终强调了目前先进的治疗策略,在体外模型的类器官旨在个性化心脏病治疗。

关键词: 心脏类器官,心脏病,再生医学,类器官技术,药物发现,个性化心脏病治疗。

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