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Review Article

聚合物纳米颗粒的修订作为提高褪黑激素生物活性的策略

卷 30, 期 29, 2023

发表于: 16 November, 2022

页: [3315 - 3334] 页: 20

弟呕挨: 10.2174/0929867329666221006113536

价格: $65

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摘要

基于纳米技术的药物输送系统与传统药理学制剂相比具有许多优势。聚合物纳米颗粒通常用作递送系统，由合成或天然聚合物组成，可保护药物在生理环境中不被降解。在这种情况下，吲哚胺褪黑激素与多种生物学功能相关，包括抗氧化、抗肿瘤、免疫调节、神经保护和心脏保护作用。然而，它的可用性、半衰期和吸收取决于给药途径，这可能会限制其治疗潜力。另一种方法是使用与褪黑激素相关的聚合物纳米颗粒制剂来增加其在感兴趣部位的生物利用度和治疗剂量。因此，本综述的目的是提供一种通用和简明的方法来研究褪黑激素和聚合物纳米颗粒之间应用于不同生物疾病的治疗关联，并强调其与可用的典型药物制剂相比的优势和潜在应用。

关键词: 聚合物纳米颗粒，褪黑激素，聚合物，抗氧化剂，抗炎剂，药物递送

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