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Review Article

生殖医学中的褪黑素：一个有希望的治疗靶点?

卷 30, 期 27, 2023

发表于: 14 November, 2022

页: [3090 - 3118] 页: 29

弟呕挨: 10.2174/0929867329666221005101031

价格: $65

摘要

褪黑激素主要从松果体释放，也在生殖器官和细胞中产生，在睡眠-觉醒周期的节律、延缓衰老过程和抗氧化/抗炎功能中起着重要作用。褪黑激素作为生殖系统的关键介质，通过调节配子和胚胎发育参与生殖过程，影响生殖疾病和妊娠结局。潜在的机制包括表观遗传和其他法规，这对于探索预防和治疗生殖疾病的新目标很有趣。本综述讨论了褪黑激素与生殖功能和功能障碍之间的关系，以及褪黑激素在生殖医学中的潜在临床应用。值得注意的是，健康与疾病的发育起源（DOHaD）与生殖密切相关，本文首次对褪黑激素与DOHaD可能关系研究的新进展进行综述。

关键词: 褪黑激素，生殖生理学，生殖病理学，DOHaD，配子形成，受精。

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