Review Article

生殖医学中的褪黑素:一个有希望的治疗靶点?

卷 30, 期 27, 2023

发表于: 14 November, 2022

页: [3090 - 3118] 页: 29

弟呕挨: 10.2174/0929867329666221005101031

价格: $65

Open Access Journals Promotions 2
摘要

褪黑激素主要从松果体释放,也在生殖器官和细胞中产生,在睡眠-觉醒周期的节律、延缓衰老过程和抗氧化/抗炎功能中起着重要作用。褪黑激素作为生殖系统的关键介质,通过调节配子和胚胎发育参与生殖过程,影响生殖疾病和妊娠结局。潜在的机制包括表观遗传和其他法规,这对于探索预防和治疗生殖疾病的新目标很有趣。本综述讨论了褪黑激素与生殖功能和功能障碍之间的关系,以及褪黑激素在生殖医学中的潜在临床应用。值得注意的是,健康与疾病的发育起源(DOHaD)与生殖密切相关,本文首次对褪黑激素与DOHaD可能关系研究的新进展进行综述。

关键词: 褪黑激素,生殖生理学,生殖病理学,DOHaD,配子形成,受精。

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