Title:Melatonin in Reproductive Medicine: A Promising Therapeutic
Target?
Volume: 30
Issue: 27
Author(s): Xueqin Feng*, Yumeng Zhang, Na Li, Yingying Zhang, Qiutong Zheng, Minya Sun, Jiaqi Tang*Zhice Xu*
Affiliation:
- Department of Obstetrics, Maternal and Child Health Care Hospital of Wuxi, Affiliated Hospital of Jining
Medical University, Shandong, China
- Institute for Fetology, First Hospital of Soochow University,
Jiangsu, China
- Department of Obstetrics, Maternal and Child Health Care Hospital of Wuxi, Affiliated Hospital of Jining
Medical University, Shandong, China
- Institute for Fetology, First Hospital of Soochow University,
Jiangsu, China
Keywords:
Melatonin, reproductive physiology, reproductive pathology, DOHaD, gamete formation, fertilization.
Abstract: Melatonin, mainly released from the pineal gland, also produced in the reproductive
organs and cells, plays important roles in rhythms of the sleep-wake cycle, retardation
of ageing processes, and antioxidant/anti-inflammatory functions. As a key mediator
in reproductive systems, melatonin is participated in the reproductive process via regulating
gamete and embryo development and influences reproductive diseases and pregnancy
outcomes. The underlying mechanisms include epigenetic and other regulations,
which are interesting for exploring new targets in the prevention and treatment of reproductive
diseases. This review discusses the relationship between melatonin and reproductive
functions and dysfunction, as well as potential clinical applications of melatonin in
reproductive medicine. Notably, Developmental Origins of Health and Diseases (DOHaD)
is closely linked to reproduction, this article is the first to review the new progress
in studies on the possible relationship between melatonin and DOHaD.