染料木黄酮的治疗潜力：临床前研究、临床证据和纳米技术应用

Title:Therapeutic Potential of Genistein: Preclinical Studies, Clinical Evidence, and Nanotechnology Application

Volume: 30 Issue: 22

关键词: 染料木黄酮，植物雌激素，多效作用，临床研究，药物输送系统，纳米技术。

摘要: Genistein (4’,5,7-trihydroxyisoflavone) is a natural plant-derived phytoestrogen that can be found, for example, in soybean seeds. Genistein is present mainly in the human diet and is a common precursor in the antimicrobial phytoalexins biosynthesis and phytoanticipins in vegetables. The interest in genistein has increased due to its pharmacological effects, including anti-cancer activity, neuroprotective effects, cardiovascular protection, anti-inflammatory effects, antioxidant activity, and prevention of obesity. The most challenging issue for improving genistein is its low oral bioavailability, which has led to many animal and human pharmacokinetic studies and numerous clinical trials. Several drug delivery systems have been developed to protect and stabilize genistein to overcome the challenge of low bioavailability. This work concerns a revision of the literature reporting nano and microformulations for genistein encapsulation, including lipid nanoparticles, liposomes, tocotrienol-rich nanoemulsions, polymeric nanoparticles, dextran complexes, chitosan complexes, and Fe₃O₄ nanoparticles with carboxymethylated chitosan. Regarding the enormous potential of genistein, several clinical trials and marketed formulations can be found in the market.

Cite this article as:

Therapeutic Potential of Genistein: Preclinical Studies, Clinical Evidence, and Nanotechnology Application, Current Medicinal Chemistry 2023; 30 (22) . https://dx.doi.org/10.2174/0929867329666221004124800