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摘要
染料木黄酮(4',5,7-三羟基异黄酮)是一种天然植物来源的植物雌激素,例如存在于大豆种子中。染料木黄酮主要存在于人类饮食中,是蔬菜中抗菌植物抗毒素生物合成和植物抗毒素的常见前体。由于其药理作用,包括抗癌活性、神经保护作用、心血管保护、抗炎作用、抗氧化活性和预防肥胖,人们对染料木黄酮的兴趣有所增加。改进染料木黄酮最具挑战性的问题是其低口服生物利用度,这导致了许多动物和人类药代动力学研究和大量临床试验。已经开发了几种药物递送系统来保护和稳定染料木黄酮,以克服低生物利用度的挑战。这项工作涉及对报告染料木黄酮包封的纳米和微制剂的文献的修订,包括脂质纳米颗粒、脂质体、富含生育三烯酚的纳米乳液、聚合物纳米颗粒、葡聚糖复合物、壳聚糖复合物和具有羧甲基化壳聚糖的 Fe3O4 纳米颗粒。关于染料木黄酮的巨大潜力,市场上可以找到一些临床试验和上市制剂。
关键词: 染料木黄酮,植物雌激素,多效作用,临床研究,药物输送系统,纳米技术。
Current Medicinal Chemistry
Title:Therapeutic Potential of Genistein: Preclinical Studies, Clinical Evidence, and Nanotechnology Application
Volume: 30 Issue: 22
关键词: 染料木黄酮,植物雌激素,多效作用,临床研究,药物输送系统,纳米技术。
摘要: Genistein (4’,5,7-trihydroxyisoflavone) is a natural plant-derived phytoestrogen that can be found, for example, in soybean seeds. Genistein is present mainly in the human diet and is a common precursor in the antimicrobial phytoalexins biosynthesis and phytoanticipins in vegetables. The interest in genistein has increased due to its pharmacological effects, including anti-cancer activity, neuroprotective effects, cardiovascular protection, anti-inflammatory effects, antioxidant activity, and prevention of obesity. The most challenging issue for improving genistein is its low oral bioavailability, which has led to many animal and human pharmacokinetic studies and numerous clinical trials. Several drug delivery systems have been developed to protect and stabilize genistein to overcome the challenge of low bioavailability. This work concerns a revision of the literature reporting nano and microformulations for genistein encapsulation, including lipid nanoparticles, liposomes, tocotrienol-rich nanoemulsions, polymeric nanoparticles, dextran complexes, chitosan complexes, and Fe3O4 nanoparticles with carboxymethylated chitosan. Regarding the enormous potential of genistein, several clinical trials and marketed formulations can be found in the market.
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Cite this article as:
Therapeutic Potential of Genistein: Preclinical Studies, Clinical Evidence, and Nanotechnology Application, Current Medicinal Chemistry 2023; 30 (22) . https://dx.doi.org/10.2174/0929867329666221004124800
DOI https://dx.doi.org/10.2174/0929867329666221004124800 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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