Review Article

考虑临床试验的综述:抗坏血酸及其衍生物的局部应用

卷 30, 期 29, 2023

发表于: 23 November, 2022

页: [3272 - 3286] 页: 15

弟呕挨: 10.2174/0929867329666221003102238

价格: $65

Open Access Journals Promotions 2
摘要

背景:由于维生素 C 的抗氧化潜力、美白作用以及它在胶原蛋白的合成和维持中发挥的重要作用,几十年来人们一直在探索维生素 C 的局部使用。由于抗坏血酸(AA)不稳定,已探索衍生分子和稳定化策略以促进将其掺入皮肤病学产品中。尽管这些分子已经上市销售,但仍然缺乏关于这些资产功效研究的科学数据,尤其是在体内。 目的:本综述的目的是调查和讨论有关维生素 C 及其最常见衍生物局部应用的问题,包括困难、偏倚和未来临床研究的前景,以更好地阐明其作用。 方法:进行文献综述以选择评估抗坏血酸和/或其衍生物局部使用的研究。 “完全可用”、“体内”和“体外”的研究被用作纳入标准。 结果:由于抗坏血酸的不稳定性,有必要研究维持甚至提高其在皮肤病产品中有效性的衍生分子。尽管如此,科学文献中对这些衍生物的研究大多是在体外进行的。近年来,可以观察到体内药效试验的增加,预计这种趋势在未来会持续下去。然而,它们提出了截然不同的方法和问题。 结论:研究稳定性、安全性、不良反应,尤其是使用相关受试者数量和标准化参数进行的体内疗效研究,对于更好地阐明局部应用维生素 C 衍生物与抗坏血酸制剂相比对皮肤的影响至关重要.

关键词: 维生素C,抗坏血酸,抗坏血酸衍生物,抗氧化剂分子,临床试验,维生素C衍生物。

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