Title:Significant Role of Long Non-coding RNAs in Parkinson’s Disease
Volume: 28
Issue: 37
Author(s): Chen Na, Chen Wen-Wen, Wang Li, Zhou Ao-Jia and Wang Ting*
Affiliation:
- Department of Pharmacy, Institute of Advanced Pharmaceutical Technology, College of Medicine, Wuhan University of Science
and Technology, Wuhan 430065, China
- Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational
Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China
Keywords:
Parkinson's disease, lncRNA, pathogenesis, neurodegenerative, apoptosis, neuroinflammation.
Abstract:
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world, with clinical manifestations of resting tremor, akinesia (or bradykinesia), rigidity, and postural instability.
However, the molecular pathogenesis of PD is still unclear, and its effective treatments are limited. Substantial
evidence demonstrates that long non-coding RNAs (lncRNAs) have important functions in various human
diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases. Therefore, the main purpose
of this study is to review the role of lncRNAs in the pathogenesis of PD.
Methods: The role of lncRNAs in the pathogenesis of PD is summarized by reviewing Pubmed.
Results: Thirty different lncRNAs are aberrantly expressed in PD and promote or inhibit PD by mediating
ubiquitin-proteasome system, autophagy-lysosomal pathway, dopamine (DA) neuronal apoptosis, mitochondrial
function, oxidative stress, and neuroinflammation.
Conclusion: In this direction, lncRNA may contribute to the treatment of PD as a diagnostic and therapeutic
target for PD.
