Title:Comparing the Effects of Pregabalin and Clonidine on Postoperative Pain
in Tonsillectomy: A Randomized, Double-blind, Prospective Clinical Trial
Volume: 17
Issue: 3
Author(s): Shahryar Sane, Rahman Abbasi Vash, Nazila Rahmani, Hadi Talebi, Parang Golabi, Farid Kalashipour, Poneh Heidari, Mohammad-Foad Hatami, Behzad Kazemi Haki*Shabnam Morwati
Affiliation:
- Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran
Keywords:
Pregabalin, clonidine, postoperative pain, tonsillectomy, clinical trial, anesthetics.
Abstract:
Background: Tonsillectomy is one of the most common surgical procedures. This
study compared the effect of Pregabalin and Clonidine on postoperative pain in adult patients
undergoing elective tonsillectomy.
Methods: This randomized, double-blind, prospective clinical trial was conducted among 92
patients aged 20 to 50. The clonidine group (C) was given 150 μg of clonidine tablet 90 minutes
before surgery, and the pregabalin group (P) was given 300 mg of pregabalin tablet 90 minutes
before surgery. The results were analyzed by SPSS 25, and statistical analysis consisted of chisquare,
T-test, and χ2 tests, and a p-value less than 0.05 was considered significant.
Results: The mean pain score and analgesic consumption scores in the pregabalin group were
lower than in the clonidine group. According to the t-test, there was a significant difference
between the two groups regarding pain score and analgesic consumption (p <0.05).
Hemodynamic variation in both groups had no significant differences (p >0.05).
Conclusion: The present study showed that pregabalin reduced postoperative pain and analgesic
consumption more effectively than clonidine.
