Title:WDFY3-AS2: A Potential Prognostic Factor and Therapeutic Target
Related to Cancer
Volume: 30
Issue: 25
Author(s): Jie Mou, Jinlan Chen, Yinxin Wu, Yuequan He, Gang Zhou*Chengfu Yuan*
Affiliation:
- College of Traditional Chinese Medicine, China Three
Gorges University, Yichang, 443002, China
- Hubei Clinical Research Center for Functional Digestive Diseases
of Traditional Chinese Medicine, Yichang Hospital of Traditional Chinese Medicine, Yichang,
443002, China
- Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional
Chinese Medicine, China Three Gorges University, Yichang 443002, China
- Medical College, China
Three Gorges University, Yichang 443002, China
- Hubei Clinical Research Center for Functional Digestive Diseases
of Traditional Chinese Medicine, Yichang Hospital of Traditional Chinese Medicine, Yichang,
443002, China
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three
Gorges University, Yichang 443002, China
Keywords:
Long non-coding RNA, WDFY3-AS2, biological market, prognosis, tumor cell, cancer.
Abstract:
Background: Abundant studies have shown that non-coding RNA is connected
with tumor cell growth, migration and invasion. As a newly discovered non-coding
RNA, WDFY3-AS2 has gradually emerged in the molecular mechanism of various tumors
and has a potential prospect as a biological indicator of tumor prognosis. This review
describes the pathophysiological mechanism and prognostic value of WDFY3-AS2
in different cancers.
Objective: This review reveals the changes and roles of WDFY3-AS2 in many tumors
and cancers. The change of WDFY3-AS2 can be used as a cancer biomarker and plays
an important role in improving tumor growth, migration and invasion. WDFY3-AS2 is
unique because it can be considered a prognostic marker for many tumors and is of great
significance for clinical diagnosis and treatment. WDFY3-AS2 shows the potential prognostic
value and the prospect of therapeutic targets in various tumors.
Methods: PubMed reviewed the related literature to analyze and summarize the regulatory
molecular mechanism of WDFY3-AS2 in various tumors and its value as a prognostic
indicator.
Results: The abnormal expression of LncRNA WDFY3-AS2 in many cancers was connected
with the poor prognosis of cancer patients, including diffuse glioma, hepatocellular
carcinoma, ovarian cancer, esophageal cancer, triple-negative breast cancer, Clear
Cell Renal Carcinoma, Esophageal squamous cell carcinoma, Lung adenocarcinoma,
which participated in the recovery of orthodontic teeth. WDFY3-AS2 has revealed the
cellular process of cancer cell growth, migration, and invasion.
Conclusion: The molecular mechanism of LncRNA WDFY3-AS2 regulating tumor specifically
proves that WDFY3-AS2 has a good prospect in the biological index of prognosis
or clinical treatment target of cancer patients.