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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Perspective

Sotorasib: First Approved KRAS Mutation Inhibitor for the Treatment of Non-small Cell Lung Cancer

Author(s): Surya K. De*

Volume 30, Issue 9, 2023

Published on: 30 September, 2022

Page: [1000 - 1002] Pages: 3

DOI: 10.2174/0929867329666220907161505

Open Access Journals Promotions 2
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Sproat, M.R.; Hofherr, M.L.; Devarakonda, S. Successful use of sotorasib in a patient with end stage renal disease on dialysis with metastatic lung adenocarcinoma: A case report. Clin. Lung Cancer, 2022, 23(6), E339-E341.
[http://dx.doi.org/10.1016/j.cllc.2022.04.007]
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Skoulidis, F.; Li, B.T.; Dy, G.K.; Price, T.J.; Falchook, G.S.; Wolf, J.; Italiano, A.; Schuler, M.; Borghaei, H.; Barlesi, F.; Kato, T.; Curioni-Fontecedro, A.; Sacher, A.; Spira, A.; Ramalingam, S.S.; Takahashi, T.; Besse, B.; Anderson, A.; Ang, A.; Tran, Q.; Mather, O.; Henary, H.; Ngarmchamnanrith, G.; Friberg, G.; Velcheti, V.; Govindan, R. Sotorasib for lung cancers with KRAS p.G12C mutation. N. Engl. J. Med., 2021, 384(25), 2371-2381.
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Fakih, M.G.; Kopetz, S.; Kuboki, Y.; Kim, T.W.; Munster, P.N.; Krauss, J.C.; Falchook, G.S.; Han, S.W.; Heinemann, V.; Muro, K.; Strickler, J.H.; Hong, D.S.; Denlinger, C.S.; Girotto, G.; Lee, M.A.; Henary, H.; Tran, Q.; Park, J.K.; Ngarmchamnanrith, G.; Prenen, H.; Price, T.J. Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): A prespecified analysis of a single-arm, phase 2 trial. Lancet Oncol., 2022, 23(1), 115-124.
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Li, J.X.; Li, R.Z.; Ma, L.R.; Wang, P.; Xu, D.H.; Huang, J.; Li, L.Q.; Tang, L.; Xie, Y.; Leung, E.L.H.; Yan, P.Y. Targeting mutant kirsten rat sarcoma viral oncogene homolog in non-small cell lung cancer: Current difficulties, integrative treatments and future perspectives. Front. Pharmacol., 2022, 13, 875330.
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Reita, D.; Pabst, L.; Pencreach, E.; Guérin, E.; Dano, L.; Rimelen, V.; Voegeli, A.C.; Vallat, L.; Mascaux, C.; Beau-Faller, M. Direct targeting KRAS mutation in non-small cell lung cancer: Focus on resistance. Cancers (Basel), 2022, 14(5), 1321.
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Haider, K.; Sharma, A.; Yar, M.S.; Yakkala, P.A.; Shafi, S.; Kamal, A. Novel approaches for the development of direct KRAS inhibitors: Structural insights and drug design. Expert Opin. Drug Discov., 2022, 17(3), 247-257.
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Rohatgi, A.; Govindan, R. Targeting KRAS G12C mutation in lung adenocarcinoma. Lung Cancer, 2022, 165, 28-33.
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Hallin, J.; Engstrom, L.D.; Hargis, L.; Calinisan, A.; Aranda, R.; Briere, D.M.; Sudhakar, N.; Bowcut, V.; Baer, B.R.; Ballard, J.A.; Burkard, M.R.; Fell, J.B.; Fischer, J.P.; Vigers, G.P.; Xue, Y.; Gatto, S.; Fernandez-Banet, J.; Pavlicek, A.; Velastagui, K.; Chao, R.C.; Barton, J.; Pierobon, M.; Baldelli, E.; Patricoin, E.F., III; Cassidy, D.P.; Marx, M.A.; Rybkin, I.I.; Johnson, M.L.; Ou, S.H.I.; Lito, P.; Papadopoulos, K.P.; Jänne, P.A.; Olson, P.; Christensen, J.G. The KRASG12C inhibitor MRTX849 provides insight toward therapeutic susceptibility of KRAS-mutant cancers in mouse models and patients. Cancer Discov., 2020, 10(1), 54-71.
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Ryan, M.B.; Coker, O.; Sorokin, A.; Fella, K.; Barnes, H.; Wong, E.; Kanikarla, P.; Gao, F.; Zhang, Y.; Zhou, L.; Kopetz, S.; Corcoran, R.B. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep., 2022, 39(12), 110993.
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