Title:The Role of High-density Lipoprotein in Oral and Dental Diseases
Volume: 30
Issue: 20
Author(s): Leila Sadeghalbanaei, Farinaz Shirban, Mohammad Bagherniya*, Thozhukat Sathyapalan and Amirhossein Sahebkar*
Affiliation:
- Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical
Sciences, Isfahan, Iran
- Biotechnology Research Center, Pharmaceutical
Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
- Applied Biomedical
Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- School of Medicine, The University
of Western Australia, Perth, Australia
- Department of Medical Biotechnology, School of Pharmacy,
Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
HDL, oropharyngeal cancer, dental health, oral health, oral disease, dental disease.
Abstract: High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins.
Beyond its well-known cardiovascular protective function, it has other actions, including
structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of
bioactive molecules, and induction of signal transduction pathways. Further, there is a
mutual connection between oral health and general health. Hence HDL could be a potentially
crucial factor relating oral health to general health. As far as we know, no comprehensive
study has been carried out to date, which has explored the association between
HDL concentration and oral diseases including lichen plan, recurrent aphthous ulcers,
candidiasis, implant osseointegration, oral cancer and precancerous conditions. Here in
this review, we summarized the relationship between HDL and oral health, suggesting a
significant association between HDL concentration and oral health.