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Review Article

MicroRNA-126在动脉粥样硬化性心血管疾病中的作用

卷 30, 期 17, 2023

发表于: 13 October, 2022

页: [1902 - 1921] 页: 20

弟呕挨: 10.2174/0929867329666220830100530

价格: $65

Open Access Journals Promotions 2
摘要

动脉粥样硬化性心血管疾病仍然是世界范围内发病率和死亡率的主要原因，尽管对其进行了所有努力。除了针对其发展的传统风险因素外，科学兴趣已转向表观遗传调控，其中微RNA（miR）处于最前沿。特别是MiR-126，已经在心血管疾病的背景下进行了广泛的研究。这种miR的表达下调与高度流行的心血管危险因素如动脉高血压和糖尿病有关。同时，其对冠状动脉疾病的诊断和预后能力仍在研究中，最新数据表明稳定疾病状态下的表达失调和急性心肌梗死。此外，miR-126的较低表达可能表明疾病复杂性较高，以及未来发生重大不良心脑血管事件的风险增加。最终，miR-126的过度表达可能成为动脉粥样硬化性心血管疾病的新的治疗靶点，因为其在促进治疗性血管生成和抗炎作用方面的潜力。然而，在转化为临床实践之前，miR治疗中存在的挑战需要解决。

关键词: miR-126，动脉粥样硬化，冠状动脉疾病，生物标志物，血管生成，炎症

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