Title:Exploring Cytokines as Potential Target in Peptic Ulcer Disease: A Systematic
Update
Volume: 23
Issue: 1
Author(s): Alveera Zubair Ansari, Nirav Yogesh Bhatia, Sankalp Ashok Gharat, Angel Pavalu Godad and Gaurav Mahesh Doshi*
Affiliation:
- Department of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Vile Parle (W), Mumbai,
India
Keywords:
Peptic ulcer disease, inflammation, cytokines, Helicobacter pylori, gastritis, host immunity.
Abstract: Peptic ulcer disease (PUD) is a widespread condition that affects millions of people
each year, with an incidence rate of 0.1%-1.5%, and has a significant impact on human health.
A range of stimuli, such as Helicobacter pylori, non-steroidal anti-inflammatory drugs, hyperacidity,
stress, alcohol, smoking, and idiopathic disease states, can produce a sore in the gastrointestinal
mucosal layer. For individuals infected with H. pylori, 2%-3% remain asymptomatic
throughout their life. Although PUD treatments are available, genetic variations occurring in
individuals because of geographical dissimilarity and antibiotic resistance pose limitations. Specifically,
inflammatory cytokine gene polymorphisms have received immense attention in recent
years because they appear to affect the severity and duration of stomach inflammation,
which is induced by H. pylori infection, contributing to the initiation of PUD. In such a context,
in-depth knowledge of interleukins may aid in the discovery of new targets and provide precautionary
approaches for the treatment of PUD. This review aims to give insights into the importance
of several interleukins that cognate with PUD and contribute to ulcer progression or
healing by activating or dampening the host immunity. Furthermore, the available targets with
clinical evidence have been explored in this review.
