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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Research Progress in Pharmacological Mechanisms, Structure-Activity Relationship and Synthesis of Sartans

Author(s): Ye-Fan Wang, Xin-Yue Ren, Wen Zhang and Guo-Wu Rao*

Volume 30, Issue 20, 2023

Published on: 21 October, 2022

Page: [2247 - 2266] Pages: 20

DOI: 10.2174/0929867329666220829101436

Price: $65

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Abstract

The sartans are a new class of antihypertensive drugs as angiotensin II receptor blockers which possess plenty of advantages in treating hypertension and related pathologies. This review describes the clinical treatment, side effects, and potential therapeutic effects of sartans from 1995 to date. The synthesis, structural-activity and molecular docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimidazole derivatives and other compounds are also described. With a clear Structure-Activity Relationship and abundant pharmacological effects, some types of novel Angiotensin Type 1 receptor antagonists are emerging gradually for further research in the meantime.

Keywords: Sartans, AT1 receptor blocker, renin-angiotensin system, structure-activity relationship, docking with AT1 receptor, synthesis.

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