Title:Current Advances and Prospects in Carbon Nanomaterials-based
Drug Deliver Systems for Cancer Therapy
Volume: 30
Issue: 24
关键词:
碳纳米材料,药物输送,癌症治疗,纳米科学,碳点,纳米钻石。
摘要: The in-depth intersection between nanoscience and oncology comes from the
fact that nanomaterials are in a similar dimension to basic biomolecules. Drug delivery
systems (DDSs), which are either targeted to a particular site or intended for the controlled
release in a particular position, have been studied extensively at the nanoscale and
are, by far, the most advanced technology in the area of nanoparticle applications. This,
consequently lead to the improvement and development of convenient administration
routes, lower toxicity, fewer side effects, and extended drug life cycle. Carbon nanomaterials
(CNMs) with favorable size and unique fluorescence properties, which was considered
an ideal candidate to transport or deliver therapeutic drugs to specific targets in a
controlled manner. The development of DDSs based on them constitutes an interesting
topic in highly effective and universal therapies to achieve better therapeutic outcomes
and reduce the side effects of malignancies. In this review, the cutting-edge progress of
CNMs in DDSs was comprehensively summarized. Additionally, the emphasis was
placed on the applications of CNMs including fullerene, graphene, carbon nanotubes (CNTs),
carbon dots (CDs), and nano-diamonds (NDs) in drug delivering. Further, we gave
some insights into the future direction and foreseeable challenges of DDSs based on
CNMs used in cancer therapy, which we hope these inspirations in DDSs associated with
anti-cancer therapy will provide perspectives in designing new drugs for further tumor
treatment.