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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Base-Promoted Regioselective Bromination of Imidazo[1,2-α]pyridines with CBr4 as Bromine Source

Author(s): Pei He, Chunbo Liu, Qinpeng Shen, Jianjun Xia, Ying Han, Wen Xiong, Zhenjie Li, Shiyun Tang, Zhihua Liu and Fengmei Zhang*

Volume 20, Issue 1, 2023

Published on: 12 September, 2022

Page: [72 - 76] Pages: 5

DOI: 10.2174/1570178619666220806111324

Price: $65

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Abstract

A bromination of hydrocarbons with CBr4 as a bromine source, promoted by NaOH, has been developed. The reaction method with high efficiency and regioselectivity for the synthesis of C3-brominated imidazo[1,2-α]pyridines. An effective and simple method of C-X bond construction has been developed, which is a supplement to the halide of imidazo[1,2-α]pyridines.

Keywords: Base-promoted, bromination, C-Br bond forming, imidazo[1, 2-α]pyridines, hydrocarbons, halide.

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