Review Article

糖尿病表观遗传反应和染色质修饰治疗的最新进展:综述

卷 30, 期 18, 2023

发表于: 26 September, 2022

页: [2020 - 2038] 页: 19

弟呕挨: 10.2174/0929867329666220802090446

价格: $65

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摘要

一些表观基因组研究报告了基因在胰岛素信号传导过程中调节脂肪生成和糖生成途径的能力,以及与心脏代谢疾病相关的其他途径。表观遗传可塑性和氧化应激在胰岛素抵抗(IR)和心脏代谢疾病的病理生理学中相互关联。这篇综述旨在确定与表观基因组的作用以及组蛋白和非组蛋白在心脏代谢疾病和胰岛素信号传导过程中的变化有关的先前研究证据,以开发有效的基于疾病的表观遗传生物标志物和基于表观遗传学的色度治疗。包括PubMed、国家医学图书馆、Medline和谷歌学者在内的多个公共数据库被搜索到同行评审和发表的报告。这项研究描绘了与心脏代谢性疾病患者的氧化应激、胰岛素信号传导、代谢性心肌病和内皮功能障碍相关的DNA/组蛋白复合物的表观遗传改变的一致证据。已经描述了跨越内脏和皮下脂肪组织的DNA甲基化和翻译后组蛋白改变都可以促进基因转录,脂肪生成作为染色质修饰酶蛋白的复杂网络,参与心脏代谢疾病患者血管系统中的防御胰岛素信号传导。据报道,白蔡芦醇、伏立诺他汀、曲古抑菌素和阿帕贝酮(Resveratrol, vorinostat, trichostatin, and apabetalone)作为表观遗传调节剂具有重要意义。基于表观遗传改变,广泛的蛋白质/基因标记物,如白细胞介素-4(IL-4)和干扰素-γ(IFN-γ)基因,可能被认为是这些患者的生物标志物,因为它们能够极化参与组织炎症和动脉粥样硬化的免疫细胞。因此,解开细胞特异性表观遗传信息对于制定心脏代谢疾病患者染色质修饰治疗的个体风险评估策略至关重要。

关键词: 表观遗传景观,心脏代谢疾病,染色质修饰疗法,糖尿病,抗氧化剂,预后。

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