Title:A Systematic Review and Meta-Analysis on the Effect of Flavonoids
on Insulin-like Growth Factor and Insulin-like Growth Factor
Binding Protein and Incidence of Breast Cancer
Volume: 30
Issue: 14
关键词:
类黄酮，胰岛素样生长因子，胰岛素样生长因子结合蛋白，乳腺癌，IGF1，IGFBP-3。
摘要:
Background: Insulin-like growth factor (IGF-1) is associated with breast cancer
in menopausal women. Naturally occurring biomolecules found in common dietary
protocols, such as flavonoids, play a key role in the inhibition and treatment of cancer.
In-vitro/in-vivo studies showed that treatment involving flavonoids led to a reduced risk
of breast cancer due to the decrease of IGF-1 level in addition to an increased insulin-like
growth factor binding protein (IGFBP)-3. However, clinical studies did not show conclusive
results in this regard because they are contradictory.
Objective: The aim of the present study was to find the effect of flavonoids on IGF-1 and
IGFBP-3 and the incidence of breast cancer.
Methods: This systematic review was performed using PubMed, Scopus, ISI Web of Science,
and EMBASE databases to collect results about the clinical use of flavonoids and
their effects on breast cancer. After eliminating duplicate articles, the title and abstract of
the remaining articles were examined in thematic communication, and related clinical articles
were selected and studied based on inclusion criteria. The data were extracted from
each article, and then statistical analysis was subsequently carried out by Comprehensive
Meta-Analysis.
Results: The results showed that the effect of flavonoids on changes in IGF1 and
IGFBP-3 was not statistically significant. No significant heterogeneity was detected
across the studies. Pooled effect size also indicated that the mean change was not statistically
significant. No significant heterogeneity was detected across the studies. There was
no evidence of publication bias for IGF1 and IGFBP-3.
Conclusion: This meta-analysis study suggests that flavonoid supplementations have no
significant effect on IGF-1 and IGFBP-3, and a high soy diet has beneficial effects on
IGF system components, which might be useful in breast cancer.
