Title:The Effects of Nano-curcumin Supplementation on Leptin and Adiponectin
in Migraine Patients: A Double-blind Clinical Trial Study from Gene
Expression to Clinical Symptoms
Volume: 23
Issue: 5
Author(s): Mohsen Sedighiyan, Elham Jafari, Sara Sohrabi Athar, Mir-Saeed Yekaninejad, Ehsan Alvandi, Mina Abdolahi and Mahmoud Djalali*
Affiliation:
- Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of
Medical Sciences, Poursina Street, Tehran, Iran
Keywords:
Migraine, leptin, adiponectin, headache, curcumin, gene expression.
Abstract:
Background: Migraine is a disabling neurogenic disorder characterized by recurrent
headache attacks. Adipokines act as inflammatory and pain mediators that contribute to migraine
pathogenesis. Leptin and adiponectin levels change in migraine patients and are associated with
headache attacks. Curcumin can exert modulatory and analgesic effects on adipokines through
several mechanisms, from gene expression to suppressing pain. The aim of the present study was
to evaluate the effects of nano-curcumin supplementation on leptin and adiponectin gene expression,
their serum levels and migraine symptoms in patients with migraine.
Methods: Forty-four episodic migraine patients enrolled in this trial were divided into two groups
as nano-curcumin (80 mg/day) and placebo group, over a two-month period. At the beginning
and the end of the study, the mRNA expression of leptin and adiponectin from isolated PBMCs
and their serum levels were measured using real-time PCR and ELISA method, respectively. The
headache frequencies, severity and duration of pain were also recorded.
Results: The results of the present research showed that nano-curcumin can up-regulate adiponectin
mRNA and increase its serum level significantly (P < 0.05). In the case of leptin, a reduction
in gene expression and concentration was found in the nano-curcumin group but it was
not statistically significant (P > 0.05). Nano-curcumin also significantly reduced the frequency,
severity and duration of headaches (P < 0.05).
Conclusion: These findings indicate that nano-curcumin supplement can be considered as a
promising approach to migraine management and clinical symptoms improvement.
