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Systematic Review Article

柑橘类黄酮和自身免疫性疾病：临床研究的系统综述

卷 30, 期 19, 2023

发表于: 03 October, 2022

页: [2191 - 2204] 页: 14

弟呕挨: 10.2174/0929867329666220629144744

价格: $65

Open Access Journals Promotions 2
摘要

背景：自身免疫性疾病是免疫系统无法识别和攻击自身健康成分的慢性疾病。在这种情况下，虽然自然疗法可能代表一种有前途的治疗策略，但关于柑橘类黄酮的证据仍然存在争议。 目的：总结并批判性地讨论柑橘类黄酮治疗自身免疫性疾病的临床证据。 方法：两位作者使用 MEDLINE、Scopus 和 ISI Web of Science 数据库独立对文章进行了系统评价。搜索词包括与柑橘类黄酮和自身免疫性疾病相关的关键词。最后一次搜索是在 2021 年 3 月 16 日进行的。没有应用语言限制。系统评价和研究选择是根据系统评价和荟萃分析 (PRISMA) 声明的首选报告项目进行的。在开始审查之前，作者定义了要包含的文章类型。三位审稿人独立进行论文提取。 结果：十项临床研究符合资格标准并被纳入最终审查。 结论：本综述中讨论的研究存在异质性。事实上，一些研究建议在自身免疫性疾病的框架内使用柑橘类黄酮，而其他研究则不鼓励这样做。因此，该系统评价强调需要进一步开展大规模临床研究，以确定柑橘类黄酮在控制自身免疫性疾病中的确切作用（PROSPERO 编号 CRD42021234903）。

关键词: 自身免疫性疾病，免疫系统，柑橘类黄酮，天然化合物，营养保健品，临床研究，系统评价，补充剂，类风湿性关节炎，牛皮癣，糖尿病，结肠炎，甲状腺炎。

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