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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Anti-Allergic Effects of Quercetin and Quercetin Liposomes in RBL-2H3 Cells

Author(s): Yanhui Zhang, Rongfa Guan* and Haizhi Huang

Volume 23, Issue 5, 2023

Published on: 31 October, 2022

Page: [692 - 701] Pages: 10

DOI: 10.2174/1871530322666220627151830

Price: $65

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Abstract

Background: Quercetin is a kind of flavonoid with important bioactivities, such as hypoglycemic, antioxidant, anti-inflammatory, and anti-allergic properties. Although it is unstable, it is worth exploring how to better exert its anti-allergic effect.

Objective: The current study aimed to elucidate the anti-allergic effect of quercetin liposomes on RBL-2H3 cells in vitro.

Methods: Quercetin liposomes were prepared to improve the anti-allergic activity of quercetin through a green thin-film dispersion method. We compared the anti-allergic effects of quercetin and quercetin liposomes in RBL-2H3 cells. The anti-allergic activity of the quercetin liposomes was evaluated by the level of β-hexosaminidase, histamine, Ca2+, IL-4, IL-8, and MCP-1.

Results: The results showed that quercetin liposomes could significantly restrain the release of β-hexosaminidase and histamine, calcium influx, and the expression of inflammatory factors, whose effect is stronger than quercetin.

Conclusion: Collectively, our research suggests that the quercetin liposome can be used as a potential allergy antagonist.

Keywords: Quercetin, liposomes, RBL-2H3 cells, anti-allergic, viability, polyhydroxy flavonoid.

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