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Review Article

用于慢性伤口愈合的细胞疗法：再生医学的未来

卷 23, 期 16, 2022

发表于: 20 October, 2022

页: [1489 - 1504] 页: 16

弟呕挨: 10.2174/138945012309220623144620

价格: $65

摘要

慢性创伤与显著的发病率和死亡率有关，需要长期有效的治疗，并对全球卫生保健系统造成巨大的财政压力。用干细胞的再生药物最近已成为一种有前途的方法，并且是一个活跃的研究领域，它们有可能分化成特定类型的细胞，从而具有自我更新，再生和免疫调节作用。此外，随着技术的兴起，各种细胞疗法和细胞类型，如骨髓和脂肪来源的间充质细胞（ADMSC），内皮祖细胞（EPC），胚胎干细胞（ESC），间充质干细胞（MSCs）和多能干细胞（PSC）被研究其对修复过程和组织再生的治疗影响。细胞疗法已被证明对提高皮肤再生和伤口修复的质量和速度具有实质性的控制作用。文献综述揭示了伤口愈合的机制，导致慢性伤口的异常以及伤口护理研究人员面临的障碍，从而探索了众多潜在改进的机会。此外，本综述的重点是在临床试验的背景下提供有关可能的细胞衍生治疗选择及其在愈合方面的相关挑战的详细信息，因为这些挑战的解决方案将为改进研究设计提供新的和更好的未来机会，从而为开发更专业的治疗方法提供大量数据。

关键词: 细胞疗法，细胞功能障碍，慢性创伤，创伤愈合，干细胞，再生医学

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